دورية أكاديمية
A single-cell tumor immune atlas for precision oncology
| العنوان: | A single-cell tumor immune atlas for precision oncology |
|---|---|
| المؤلفون: | Nieto, Paula, Elosua Bayes, Marc, Trincado, Juan L., Marchese, Domenica, Massoni Badosa, Ramon, Salvany, Maria, Henriques, Ana, Nieto, Juan, Aguilar Fernández, Sergio, Mereu, Elisabetta, Moutinho, Cátia, Ruiz, Sara, Lorden, Patricia, Chin, Vanessa T., Kaczorowski, Dominik, Chan, Chia-Ling, Gallagher, Richard, Chou, Angela, Planas Rigol, Ester, Rubio Perez, Carlota, Gut, Ivo G., Piulats, Josep M., Seoane, Joan, Powell, Joseph E., Batlle, Eduard, Heyn, Holger |
| المصدر: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| بيانات النشر: | Cold Spring Harbor Laboratory |
| سنة النشر: | 2021 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Immunitat cel·lular, Càncer, Cellular immunity, Cancer |
| الوصف: | The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis and treatment response lack precision. A comprehensive compendium of tumor immune cells is required to pinpoint predictive cellular states and their spatial localization. We generated a single-cell tumor immune atlas, jointly analyzing published data sets of >500,000 cells from 217 patients and 13 cancer types, providing the basis for a patient stratification based on immune cell compositions. Projecting immune cells from external tumors onto the atlas facilitated an automated cell annotation system. To enable in situ mapping of immune populations for digital pathology, we applied SPOTlight, combining single-cell and spatial transcriptomics data and identifying colocalization patterns of immune, stromal, and cancer cells in tumor sections. We expect the tumor immune cell atlas, together with our versatile toolbox for precision oncology, to advance currently applied stratification approaches for prognosis and immunotherapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 15 p.; application/pdf |
| اللغة: | English |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1101/gr.273300.120Test; Genome Research, 2021, vol. 31, num. 10, p. 1913-1926; https://doi.org/10.1101/gr.273300.120Test; info:eu-repo/grantAgreement/EC/H2020/810287/EU//BCLLatlas; 1088-9051/21; http://hdl.handle.net/2445/180737Test |
| الإتاحة: | https://doi.org/10.1101/gr.273300.120Test http://hdl.handle.net/2445/180737Test |
| حقوق: | cc by-nc (c) Nieto, Paula et al, 2021 ; http://creativecommons.org/licenses/by-nc/3.0/esTest/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7E254FE3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |