دورية أكاديمية
Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma
| العنوان: | Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma |
|---|---|
| المؤلفون: | Tejera Vaquerizo, Antonio, Nagore, Eduardo, Puig i Sardà, Susana, Robert, Caroline, Saiag, Philippe, Martín-Cuevas, Paula, Gallego, Elena, Herrera Acosta, Enrique, Aguilera, José, Malvehy, J. (Josep), Carrera Álvarez, Cristina, Cavalcanti, Andrea, Rull, Ramón, Vilalta Solsona, Antonio, Lannoy, Emilie, Boutros, Celine, Benannoune, Naima, Tomasic, Gorana, Aegerte, Philippe, Vidal i Sicart, Sergi, Palou, Josep, Alós i Hernández, Llúcia, Requena, Celia, Traves, Víctor, Pla, Ángel, Bolumar, Isidro, Soriano, Virtudes, Guillén, Carlos, Herrera Ceballos, Enrique |
| المصدر: | Articles publicats en revistes (Medicina) |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2015 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Melanoma, Càncer de pell, Nodes limfàtics, Skin cancer, Lymph nodes |
| الوصف: | Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 24 p.; application/pdf |
| اللغة: | English |
| تدمد: | 0959-8049 |
| العلاقة: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejca.2015.05.023Test; European Journal of Cancer, 2015, vol. 51, num. 13, p. 1780-1793; https://doi.org/10.1016/j.ejca.2015.05.023Test; http://hdl.handle.net/2445/130565Test; 660002 |
| الإتاحة: | https://doi.org/10.1016/j.ejca.2015.05.023Test http://hdl.handle.net/2445/130565Test |
| حقوق: | cc-by-nc-nd (c) Elsevier B.V., 2015 ; http://creativecommons.org/licenses/by-nc-nd/3.0/esTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.99083FF5 |
| قاعدة البيانات: | BASE |
| تدمد: | 09598049 |
|---|