دورية أكاديمية
Induced pluripotent stem cells, a stepping stone to in vitro human models of hearing loss
| العنوان: | Induced pluripotent stem cells, a stepping stone to in vitro human models of hearing loss |
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| المؤلفون: | Durán Alonso, Beatriz, Petković, Hrvoje |
| المساهمون: | CSIC-UVA - Instituto de Biología y Genética Molecular (IBGM), Junta de Castilla y León |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Hearing loss, Human induced pluripotent stem cell (hiPSC), Inner ear |
| الوصف: | Hearing loss is the most prevalent sensorineural impairment in humans. Yet despite very active research, no effective therapy other than the cochlear implant has reached the clinic. Main reasons for this failure are the multifactorial nature of the disorder, its heterogeneity, and a late onset that hinders the identification of etiological factors. Another problem is the lack of human samples such that practically all the work has been conducted on animals. Although highly valuable data have been obtained from such models, there is the risk that inter-species differences exist that may compromise the relevance of the gathered data. Human-based models are therefore direly needed. The irruption of human induced pluripotent stem cell technologies in the field of hearing research offers the possibility to generate an array of otic cell models of human origin; these may enable the identification of guiding signalling cues during inner ear development and of the mechanisms that lead from genetic alterations to pathology. These models will also be extremely valuable when conducting ototoxicity analyses and when exploring new avenues towards regeneration in the inner ear. This review summarises some of the work that has already been conducted with these cells and contemplates future possibilities. ; M.B.D.-A. gratefully acknowledges the intramural research funding from the IBGM-Consejería de Sanidad de la Junta de Castilla y León and acknowledges Laura Sánchez-Sánchez for her kind assistance with the bibliographic content. M.B.D.-A. and H.P. thank RNID/Action on Hearing Loss for TRIH grant funding (grant no. T3_Petkovic). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Publisher's version; http://dx.doi.org/10.3390/cells11203331Test; Sí; e-issn: 2073-4409; Cells 11(20): 3331 (2022); http://hdl.handle.net/10261/296258Test |
| DOI: | 10.3390/cells11203331 |
| الإتاحة: | https://doi.org/10.3390/cells11203331Test http://hdl.handle.net/10261/296258Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.C6E38861 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells11203331 |
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