دورية أكاديمية
Active viscosupplements for osteoarthritis treatment
| العنوان: | Active viscosupplements for osteoarthritis treatment |
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| المؤلفون: | Pontes-Quero, G. M., García-Fernández, L., Aguilar, María Rosa, San Román, Julio, Pérez Cano, J., Vázquez-Lasa, Blanca |
| المساهمون: | Comunidad de Madrid |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Viscoelasticity, Anti-inflammatory drugs, Hyaluronic acid, Synovial fluid, Intraarticular administration |
| الوصف: | Objective: Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory drugs for pain relief. Combination of viscosupplements with chemical agents or drugs is emerging as a new strategy to provide a double action of synovial fluid viscoelasticity recovery and the therapeutic effect of the bioactive principle. Methods: In this review, we present the latest research on the combination of viscosupplements with active molecules. We conducted a literature review of articles published in different web search engines and categorized according to the active molecule introduced into the viscosupplement. Results: Generally, the introduction of anti-inflammatory molecules have shown to improve pain relief although some cytotoxicity has been demonstrated especially for non-steroidal anti-inflammatory drugs. Other molecules such as antioxidant or disease modifying osteoarthritis drugs have been reported to improve viscosupplementation action. Drug delivery systems combined with hyaluronic acid could enhance the activity of the encapsulated molecules and provide better control over the drug release. Finally, biological approaches such as the use of stem cells or platelet-rich plasma seem to be the most promising strategies for cartilage recovery. Conclusions: Combination therapy of viscosupplements with therapeutic agents, drug delivery systems or regenerative therapies can improve viscosupplementation outcome in terms of pain relief and joint functionality. However, further research is needed in order to reach more conclusive results. ; This work was developed as part of the project IND2017/IND7614, supported ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1532-866X |
| العلاقة: | http://dx.doi.org/10.1016/j.semarthrit.2019.02.008Test; Sí; e-issn: 0049-0172; Seminars in Arthritis and Rheumatism (2019); http://hdl.handle.net/10261/183514Test; http://dx.doi.org/10.13039/100012818Test |
| DOI: | 10.1016/j.semarthrit.2019.02.008 |
| DOI: | 10.13039/100012818 |
| الإتاحة: | https://doi.org/10.1016/j.semarthrit.2019.02.008Test https://doi.org/10.13039/100012818Test http://hdl.handle.net/10261/183514Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.225CBCE7 |
| قاعدة البيانات: | BASE |
| تدمد: | 1532866X |
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| DOI: | 10.1016/j.semarthrit.2019.02.008 |