دورية أكاديمية
Daily consumption of wild olive (acebuche) oil reduces blood pressure and ameliorates endothelial dysfunction and vascular remodelling in rats with NG-nitro-L-arginine methyl ester-induced hypertension
| العنوان: | Daily consumption of wild olive (acebuche) oil reduces blood pressure and ameliorates endothelial dysfunction and vascular remodelling in rats with NG-nitro-L-arginine methyl ester-induced hypertension |
|---|---|
| المؤلفون: | Reyes-Goya, Claudia, Santana-Garrido, Álvaro, Aguilar-Espejo, Gema, Pérez Camino, María del Carmen, Mate, Alfonso, Vázquez, Carmen M. |
| المساهمون: | Junta de Andalucía |
| بيانات النشر: | Cambridge University Press Nutrition Society (Great Britain) |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Acebuche, Aorta, Arterial hypertension, Endothelial dysfunction, NG-nitro-l-arginine methyl ester, Wild olive oil |
| الوصف: | 14 Páginas.-- 6 Figuras.-- 3 Tablas ; Despite numerous reports on the beneficial effects of olive oil in the cardiovascular context, very little is known about the olive tree's wild counterpart (Olea europaea, L. var. sylvestris), commonly known as acebuche (ACE) in Spain. The aim of this study was to analyse the possible beneficial effects of an extra virgin ACE oil on vascular function in a rodent model of arterial hypertension (AH) induced by NG-nitro-l-arginine methyl ester (L-NAME). Four experimental groups of male Wistar rats were studied: (1) normotensive rats (Control group); (2) normotensive rats fed a commercial diet supplemented with 15 % (w/w) ACE oil (Acebuche group); (3) rats made hypertensive following administration of L-NAME (L-NAME group); and (4) rats treated with L-NAME and simultaneously supplemented with 15 % ACE oil (LN + ACE group). All treatments were maintained for 12 weeks. Besides a significant blood pressure (BP)-lowering effect, the ACE oil-enriched diet counteracted the alterations found in aortas from hypertensive rats in terms of morphology and responsiveness to vasoactive mediators. In addition, a decrease in hypertension-related fibrotic and oxidative stress processes was observed in L-NAME-treated rats subjected to ACE oil supplement. Therefore, using a model of AH via nitric oxide depletion, here we demonstrate the beneficial effects of a wild olive oil based upon its vasodilator, antihypertensive, antioxidant, antihypertrophic and antifibrotic properties. We postulate that regular inclusion of ACE oil in the diet can alleviate the vascular remodelling and endothelial dysfunction processes typically found in AH, thus resulting in a significant reduction of BP. ; We thank the Centro de Innovación, Tecnología e Innovación de la Universidad de Sevilla (CITIUS, Servicio de Biología, Servicio de Microscopía) for technical support. The authors are especially grateful to Alcazarín Reunidos FP, S.L. (Monda, Málaga, Spain) for providing the extra virgin wild olive oil (ACE oil) used ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 00071145 35000635 |
| العلاقة: | The British journal of nutrition; Publisher's version; http://dx.doi.org/10.1017/S0007114522000034Test; Sí; British Journal of Nutrition 128 (7): 1206–1219 (2022); http://hdl.handle.net/10261/282797Test; http://dx.doi.org/10.13039/501100011011Test; 2-s2.0-85123513488; https://api.elsevier.com/content/abstract/scopus_id/85123513488Test |
| DOI: | 10.1017/S0007114522000034 |
| DOI: | 10.13039/501100011011 |
| الإتاحة: | https://doi.org/10.1017/S0007114522000034Test https://doi.org/10.13039/501100011011Test http://hdl.handle.net/10261/282797Test https://api.elsevier.com/content/abstract/scopus_id/85123513488Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.4E20A6F0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00071145 35000635 |
|---|---|
| DOI: | 10.1017/S0007114522000034 |