دورية أكاديمية
Simple non-invasive scoring systems and histological scores in predicting mortality in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
| العنوان: | Simple non-invasive scoring systems and histological scores in predicting mortality in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis |
|---|---|
| المؤلفون: | Lui, Chang-Hai, Ampuero, Javier, Pavlides, Michael, Wai-Sun Wong, Vincent, Fan, Jian-Gao, Bai, Lang, Li, Hong, Wu, Dong-Bo, Zhou, Ling-Yun, Du, Ling-Yao, Yang, Tian-Kuo, Jiang, Wei, Shi, Ying, Gil-Gómez, Antonio, Zhang, Wen-Ting, Liang, Jia-Xu, Romero-Gómez, Manuel, Tang, Hong |
| بيانات النشر: | John Wiley & Sons |
| سنة النشر: | 2021 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Key wordshistological scores, NAS histological features, Non-alcoholic fatty liver disease, Predictingmortality, Simple non-invasive scoring systems |
| الوصف: | [Background and Aim] There is debate among the hepatology community regarding the simple non-invasive scoring systems and histological scores (even it was developed for histological classification) in predicting clinical outcomes in patients with non-alcoholic fatty liver disease (NAFLD). This study aimed to determine whether the presence of simple non-invasive scoring systems and histological scores could predict all-cause mortality, liver-related mortality, and liver disease decompensation (liver failure, cirrhosis, hepatocellular carcinoma, or decompensated liver disease). ; [Methods] The pooled hazard ratio of prognostic factors and incidence rate per 1000 person-years in patients with NAFLD was calculated and further adjusted by two different models of handling the duplicated data. ; [Results] A total of 19 longitudinal studies were included. Most simple non-invasive scoring systems (Fibrosis-4 Score, BARD, and aspartate aminotransferase-to-platelet ratio index ) and histological scores (NAFLD activity score, Brunt, and "steatosis, activity, and fibrosis" ) failed in predicting mortality, and only the NAFLD fibrosis score > 0.676 showed prognostic ability to all-cause mortality (four studies, 7564 patients, 118 352 person-years followed up, pooled hazard ratio 1.44, 95% confidence interval [CI] 1.05–1.96). The incidence rate per 1000 person-years of all-cause mortality, liver-related mortality, cardiovascular-related mortality, and liver disease decompensation resulted in a pooled incidence rate per 1000 person-years of 22.65 (14 studies, 95% CI 9.62–53.31), 3.19 (7 studies, 95% CI 1.14–8.93), 6.02 (6 studies, 95% CI 4.69–7.74), and 11.46 (4 studies, 95% CI 5.33–24.63), respectively. ; [Conclusion] Non-alcoholic fatty liver disease fibrosis score showed promising prognostic value to all-cause mortality. Most present simple non-invasive scoring systems and histological scores failed to predict clinical outcomes. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0815-9319 |
| العلاقة: | http://dx.doi.org/10.1111/jgh.15431Test; Sí; e-issn: 1440-1746; Journal of Gastroenterology and Hepatology 36(7): 1754-1768 (2021); http://hdl.handle.net/10261/266248Test |
| DOI: | 10.1111/jgh.15431 |
| الإتاحة: | https://doi.org/10.1111/jgh.15431Test http://hdl.handle.net/10261/266248Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.5DA82EF1 |
| قاعدة البيانات: | BASE |
| تدمد: | 08159319 |
|---|---|
| DOI: | 10.1111/jgh.15431 |