دورية أكاديمية
Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans
| العنوان: | Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans |
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| المؤلفون: | Sharma, Rahul, Jost, Daniel, Kind, Jop, Gómez-Saldívar, Georgina, Steensel, Bas van, Askjaer, Peter, Vaillant, Cédric, Meister, Peter |
| المساهمون: | Swiss National Science Foundation, Swiss Foundation for Research on Muscle Diseases, University of Bern, Centre National de la Recherche Scientifique (France), Ecole Normale Supérieure de Lyon, Ministerio de Economía y Competitividad (España), European Commission, Netherlands Organization for Scientific Research, Netherlands Organisation for Health Research and Development |
| بيانات النشر: | Cold Spring Harbor Laboratory Press |
| سنة النشر: | 2014 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months. After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International). ; The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites. ; Our laboratories are supported by the Swiss National Science Foundation (SNF assistant professor grant PP00P3_133744), the Swiss Foundation forMuscle Diseases Research, and the University of Bern (to P.M.); the French Centre National de la Recherche Scientifique and the Ecole Normale Sup erieure de Lyon (to C.V. and D.J.); the Spanish Ministry of Economy and Competitiveness (BFU2010-15478), the European Regional Development Fund (to P.A.); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)-Aard en Levenswetenschappen (ALW) Veni (to J.K.); and ZonMW (Medische wetenschappen)-TOP (to B.v.S.). ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0890-9369 1549-5477 |
| العلاقة: | Publisher's version; http://dx.doi.org/10.1101/gad.248864.114Test; Sí; Genes and Development 28: 2591-2596 (2014); http://hdl.handle.net/10261/122587Test; http://dx.doi.org/10.13039/100009068Test; http://dx.doi.org/10.13039/501100004794Test; http://dx.doi.org/10.13039/501100003329Test; http://dx.doi.org/10.13039/501100000780Test |
| DOI: | 10.1101/gad.248864.114 |
| DOI: | 10.13039/100009068 |
| DOI: | 10.13039/501100004794 |
| DOI: | 10.13039/501100003329 |
| DOI: | 10.13039/501100000780 |
| الإتاحة: | https://doi.org/10.1101/gad.248864.114Test https://doi.org/10.13039/100009068Test https://doi.org/10.13039/501100004794Test https://doi.org/10.13039/501100003329Test https://doi.org/10.13039/501100000780Test http://hdl.handle.net/10261/122587Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.989B29D0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 08909369 15495477 |
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| DOI: | 10.1101/gad.248864.114 |