دورية أكاديمية
Human T-lymphotropic virus type 1 infection and disease in Spain
| العنوان: | Human T-lymphotropic virus type 1 infection and disease in Spain |
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| المؤلفون: | Mendoza, Carmen de, Caballero, Estrella, Aguilera, Antonio, Requena, Silvia, Ortiz de Lejarazu, Raúl, Pirón, María, González, Rocío, Jiménez, Ana, Roc, Lourdes, Treviño, Ana, Benito, Rafael, Fernández-Alonso, Miriam, Aguinaga, Aitziber, Rodríguez, Carmen, García-Costa, Juan, Blanco, Lidia, Ramos, José M., Calderón, Enrique J., Eirós, José M., Sauleda, Silvia, Barreiro, Pablo, Soriano, Vicente |
| المساهمون: | Instituto de Salud Carlos III, European Commission |
| بيانات النشر: | Lippincott Williams & Wilkins |
| سنة النشر: | 2017 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Adult T-cell leukemia, Blood banks, Epidemiology, Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis, Human T-lymphotropic virus type, Transplantation |
| الوصف: | Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants). To date there is neither prophylactic vaccine nor effective antiviral therapy. A total of 327 cases of HTLV-1 infection had been reported at the HTLV-1 Spanish registry until December 2016, of whom 34 had been diagnosed with TSP and 25 with ATL. Overall 62% were Latin American immigrants and 13% were persons of African origin. The incidence of HTLV-1 in Spain has remained stable for nearly a decade with 20–25 new cases yearly. Of the 21 newly diagnosed HTLV-1 cases during year 2016, one was a native Spaniard pregnant woman, and four presented with symptomatic disease, including three with ATL and one with TSP. Underdiagnosis of HTLV-1 in Spain must be high (iceberg model), which may account for the disproportionate high rate of symptomatic cases (almost 20%) and the late recognition of preventable HTLV-1 transmissions in special populations, such as newborns and transplant recipients. Our current estimate is of 10 000 persons living with HTLV-1 infection in Spain. Given the large flux of immigrants and visitors from HTLV-1 endemic regions to Spain, the expansion of HTLV-1 screening policies is warranted. At this time, it seems worth recommending HTLV testing to all donor/recipient organ transplants and pregnant women regardless place of birth. Although current leukoreduction procedures largely prevent HTLV-1 transmission by blood transfusions, HTLV testing of all first-time donors should be cost-effective contributing to unveil asymptomatic unaware HTLV-1 carriers. ; The work was funded in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0269-9370 1473-5571 |
| العلاقة: | https://doi.org/10.1097/QAD.0000000000001527Test; Sí; AIDS 31(12): 1653-1663 (2017); http://hdl.handle.net/10261/182228Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100004587Test |
| DOI: | 10.1097/QAD.0000000000001527 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004587 |
| الإتاحة: | https://doi.org/10.1097/QAD.0000000000001527Test https://doi.org/10.13039/501100000780Test https://doi.org/10.13039/501100004587Test http://hdl.handle.net/10261/182228Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.BD34D2EF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02699370 14735571 |
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| DOI: | 10.1097/QAD.0000000000001527 |