دورية أكاديمية
Mitochondrial cholesterol in health and disease
| العنوان: | Mitochondrial cholesterol in health and disease |
|---|---|
| المؤلفون: | García-Ruiz, Carmen, Marí, Montserrat, Colell Riera, Anna, Morales, Albert, Caballero, Francisco, Montero, Joan, Terrones, Oihana, Basañez, Gorka, Fernández-Checa, José C. |
| بيانات النشر: | Universidad de Murcia |
| سنة النشر: | 2009 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Cholesterol, Mitochondria, Oxidative stress, Glutathione, Membrane dynamics |
| الوصف: | Trabajo presentado al Mitochondrial Dynamics: from mechanisms to disease celebrado en Italia del 11 al 15 de septiembre de 2011. ; Cholesterol is a critical component of biological membranes, which not only plays an essential role in determining membrane physical properties, but also in the regulation of multiple signaling pathways. Cells satisfy their need for cholesterol either by uptake from nutrients and lipoproteins or de novo synthesis from acetyl-CoA. The latter process occurs in the endoplasmic reticulum, where transcription factors that regulate the expression of enzymes involved in the de novo cholesterol synthesis reside. Cholesterol is distributed to different membranes most prominently to plasma membrane, where it participates in the physical organization of specific membrane domains. Mitochondria, however, are considered cholesterol-poor organelles, and obtain their cholesterol load by the action of specialized proteins involved in its delivery from extramitochondrial sources and trafficking within mitochondrial membranes. Although mitochondrial cholesterol fulfills vital physiological functions, such as the synthesis of bile acids in the liver or the formation of steroid hormones in specialized tissues, recent evidence indicates that the accumulation of cholesterol in mitochondria may be a key step in disease progression, including steatohepatitis, carcinogenesis or Alzheimer disease ; This work was supported in part by the Research Center for Liver and Pancreatic Diseases Grant P50 AA 11999 funded by the US National Institute on Alcohol Abuse and Alcoholism, Plan Nacional de I+D Grants: SAF2005-03923, SAF2005-03943, SAF2006- 06780, BFU2005-06095, and FIS06/0395 and by the Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD) supported by the Instituto de Salud Carlos III. M.M. is an IDIBAPS investigator, A.C. is supported by the Ramón y Cajal Research Program (MEC), and O.T. is a recipient of a predoctoral fellowship from the Basque Government. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0213-3911 1699-5848 |
| العلاقة: | http://www.hh.um.es/Abstracts/Vol_24/24_1/24_1_117.htmTest; Histology and Histopathology 24(1): 117-132 (2009); http://hdl.handle.net/10261/32074Test |
| الإتاحة: | http://hdl.handle.net/10261/32074Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.4A7B5F4 |
| قاعدة البيانات: | BASE |
| تدمد: | 02133911 16995848 |
|---|