دورية أكاديمية
Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypo-Thalamic Orexin Neurons
| العنوان: | Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypo-Thalamic Orexin Neurons |
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| المؤلفون: | Pignatelli Garrigos, Jaime, Fernandez de Sevilla, M.E., Sperber, Jacob, Horrillo, Daniel, Medina-Gómez, Gema, Torres Alemán, Ignacio |
| المساهمون: | Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Comunidad de Madrid |
| بيانات النشر: | Molecular Diversity Preservation International |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | IGF-I, Central control of metabolism, Circadian activity, Feeding entrainment, Orexin |
| الوصف: | Uncoupling of metabolism and circadian activity is associated with an increased risk of a wide spectrum of pathologies. Recently, insulin and the closely related insulin-like growth factor I (IGF-I) were shown to entrain feeding patterns with circadian rhythms. Both hormones act centrally to modulate peripheral glucose metabolism; however, whereas central targets of insulin actions are intensely scrutinized, those mediating the actions of IGF-I remain less defined. We recently showed that IGF-I targets orexin neurons in the lateral hypothalamus, and now we evaluated whether IGF-I modulates orexin neurons to align circadian rhythms with metabolism. Mice with disrupted IGF-IR activity in orexin neurons (Firoc mice) showed sexually dimorphic alterations in daily glucose rhythms and feeding activity patterns which preceded the appearance of metabolic disturbances. Thus, Firoc males developed hyperglycemia and glucose intolerance, while females developed obesity. Since IGF-I directly modulates orexin levels and hepatic expression of KLF genes involved in circadian and metabolic entrainment in an orexin-dependent manner, it seems that IGF-I entrains metabolism and circadian rhythms by modulating the activity of orexin neurons. ; This research was funded by a grant from Ciberned (Instituto de Salud Carlos III, Spain), an Inter-CIBER project (PIE14/00061), part of the projects PID2019-104376RB-I00 funded by MCIN/AEI/10.13039/ 501100011033; and a grant by Comunidad de Madrid through the European Social Fund (ESF)-financed program NEUROMETAB-CM (B2017/BMD-3700) to ITA. Sperber, Jacob was funded by a Fulbright grant. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104376RB-I00/ES/PLASTICIDAD AFECTIVA: MODULACION DEL ESTADO DE ANIMO POSITIVO POR PEPTIDOS INSULINICOS/; info:eu-repo/grantAgreement/MINECO//PIE14/2F00061/ES/Molecular links between diabetes and neurodegenerative disorders/; Publisher's version; http://dx.doi.org/10.3390/ijms23094679Test; Sí; International Journal of Molecular Sciences 23(9): 4679 (2022); http://hdl.handle.net/10261/278666Test; http://dx.doi.org/10.13039/100012818Test; http://dx.doi.org/10.13039/501100004587Test; http://dx.doi.org/10.13039/501100004837Test; http://dx.doi.org/10.13039/501100011033Test |
| DOI: | 10.3390/ijms23094679 |
| DOI: | 10.13039/100012818 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100004837 |
| DOI: | 10.13039/501100011033 |
| الإتاحة: | https://doi.org/10.3390/ijms23094679Test https://doi.org/10.13039/100012818Test https://doi.org/10.13039/501100004587Test https://doi.org/10.13039/501100004837Test https://doi.org/10.13039/501100011033Test http://hdl.handle.net/10261/278666Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.5290972B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23094679 |