التفاصيل البيبلوغرافية
| العنوان: |
Long-term low dose interferon alpha-2b in the treatment of chronic hepatitis B in multi-ethnic patients in Hawaii. |
| المؤلفون: |
Ching, Nathaniel P. H., Lumeng, J, Pang, R, Pang, G, Or, F W, Ching, Natascha W. H., Ching, Clara |
| المجموعة: |
Digital Repository of the University of Hawaii at Manoa |
| مصطلحات موضوعية: |
Adjuvants, Immunologic/therapeutic use, Adult, Biomarkers/blood, Ethnic Groups, Female, Hepatitis B/ethnology/therapy, Hepatitis, Chronic/ethnology/therapy, Humans, Interferon-alpha/adverse effects/therapeutic use, Liver Function Tests, Male, Middle Aged, Recombinant Proteins |
| الوصف: |
The antiviral and immunomodulatory effects of interferon were assessed in the treatment of chronic hepatitis B in multi-ethnic patients to prevent viral replication and chronic liver damage. Five million units of recombinant interferon alpha-2b were administered three times a week for 48 weeks to a group of 18 chronic active hepatitis B patients. A complete response was defined as seroconversion to anti-HBe and/or loss of HBe antigen. Seroconversion to anti-HBe in 5 of 12 (42%) chronic active hepatitis B patients occurred after 48 weeks of therapy. HBV-DNA decreased to undetectable levels in 8 of 12 (67%) patients. This chronic low-dose interferon administration regimen demonstrated responses comparable to other studies. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0017-8594 |
| العلاقة: |
http://hdl.handle.net/10524/54086Test; 8942117 |
| الإتاحة: |
http://hdl.handle.net/10524/54086Test |
| رقم الانضمام: |
edsbas.6ACCD1CF |
| قاعدة البيانات: |
BASE |
