دورية أكاديمية
Mineralocorticoid receptors in non‐alcoholic fatty liver disease
| العنوان: | Mineralocorticoid receptors in non‐alcoholic fatty liver disease |
|---|---|
| المؤلفون: | Schreier, Barbara, Zipprich, Alexander, Uhlenhaut, Henriette, Gekle, Michael |
| سنة النشر: | 2022 |
| المجموعة: | Digital Library Thüringen |
| مصطلحات موضوعية: | article, ScholarlyArticle, ddc:610, aldosterone, cirrhosis, hepatic stellate cell, hepatocytes, liver, mineralocorticoid receptor, NAFL |
| الوصف: | Liver diseases are the fourth common death in Europe responsible for about 2 million death per year worldwide. Among the known detrimental causes for liver dysfunction are virus infections, intoxications and obesity. The mineralocorticoid receptor (MR) is a ligand‐dependent transcription factor activated by aldosterone or glucocorticoids but also by pathological milieu factors. Canonical actions of the MR take place in epithelial cells of kidney, colon and sweat glands and contribute to sodium reabsorption, potassium secretion and extracellular volume homeostasis. The non‐canonical functions can be initiated by inflammation or an altered micro‐milieu leading to fibrosis, hypertrophy and remodelling in various tissues. This narrative review summarizes the evidence regarding the role of MR in portal hypertension, non‐alcoholic fatty liver disease, liver fibrosis and cirrhosis, demonstrating that inhibition of the MR in vivo seems to be beneficial for liver function and not just for volume regulation. Unfortunately, the underlying molecular mechanisms are still not completely understood. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 13 Seiten |
| اللغة: | English |
| العلاقة: | British Journal of Pharmacology -- Br J Pharmacol -- BJP online -- 0007-1188 -- 1476-5381; https://doi.org/10.1111/bph.15784Test; https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20221005-150639-000Test; https://www.db-thueringen.de/receive/dbt_mods_00053515Test; https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00057358/BPH_BPH15784.pdfTest |
| DOI: | 10.1111/bph.15784 |
| الإتاحة: | https://doi.org/10.1111/bph.15784Test https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20221005-150639-000Test https://www.db-thueringen.de/receive/dbt_mods_00053515Test https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00057358/BPH_BPH15784.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ ; public ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1EDB39C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bph.15784 |
|---|