دورية أكاديمية
A Detailed Review on the Phytochemical Profiles and Anti-Diabetic Mechanisms of Momordica Charantia
العنوان: | A Detailed Review on the Phytochemical Profiles and Anti-Diabetic Mechanisms of Momordica Charantia |
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المؤلفون: | Oyelere, Sunday F., Ajayi, Oluwatobi H., Ayoade, Titilayo E., Santana Pereira, George Bueno, Dayo Owoyemi, Bolaji C., Ilesanmi, Ajibola O., Akinyemi, Olalekan A. |
المصدر: | ETSU Faculty Works |
بيانات النشر: | Digital Commons @ East Tennessee State University |
سنة النشر: | 2022 |
المجموعة: | Digital Commons @ East Tennessee State University |
مصطلحات موضوعية: | anti-diabetic, cucurbitaceae, diabetes mellitus, hyperglycemia, hypoglycemic, momordica charantia, phytochemical, Biological Sciences |
الوصف: | Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million people globally, with an annual mortality of more than one million people. This high mortality rate highlights the need for in-depth study of anti-diabetic agents. This review explores the phytochemical contents and anti-diabetic mechanisms of (cucurbitaceae). Studies show that contains several phytochemicals that have hypoglycemic effects, thus, the plant may be effective in the treatment/management of diabetes mellitus. Also, the biochemical and physiological basis of anti-diabetic actions is explained. exhibits its anti-diabetic effects via the suppression of MAPKs and NF-κβin pancreatic cells, promoting glucose and fatty acids catabolism, stimulating fatty acids absorption, inducing insulin production, ameliorating insulin resistance, activating AMPK pathway, and inhibiting glucose metabolism enzymes (fructose-1,6-bisphosphate and glucose-6-phosphatase). Reviewed literature was obtained from credible sources such as PubMed, Scopus, and Web of Science. |
نوع الوثيقة: | text |
اللغة: | unknown |
العلاقة: | https://dc.etsu.edu/etsu-works-2/12Test; https://doi.org/10.1016/j.heliyon.2022.e09253Test |
DOI: | 10.1016/j.heliyon.2022.e09253 |
الإتاحة: | https://doi.org/10.1016/j.heliyon.2022.e09253Test https://dc.etsu.edu/etsu-works-2/12Test |
رقم الانضمام: | edsbas.9F594A4B |
قاعدة البيانات: | BASE |
DOI: | 10.1016/j.heliyon.2022.e09253 |
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