دورية أكاديمية
Association of RS2200733 but Not RS10033464 on 4q25 With Atrial Fibrillation Based on the Recessive Model in a Taiwanese Population
| العنوان: | Association of RS2200733 but Not RS10033464 on 4q25 With Atrial Fibrillation Based on the Recessive Model in a Taiwanese Population |
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| المؤلفون: | Lee, Kun T., Yeh, Hi Y., Tung, Chung P., Chu, Chih S., Cheng, Kai H., Tsai, Wei C., Lu, Ye Hsu, Chang, Jan G., Sheu, Sheng H., Lai, Wen T. |
| المصدر: | ETSU Faculty Works |
| بيانات النشر: | Digital Commons @ East Tennessee State University |
| سنة النشر: | 2010 |
| المجموعة: | Digital Commons @ East Tennessee State University |
| مصطلحات موضوعية: | atrial fibrillation, multiplex single base extension, single nucleotide polymorphism |
| الوصف: | Objectives: To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population. Methods: We enrolled 200 patients with AF (mean age: 67 ± 13 years) and 158 controls (mean age: 63 ± 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods. Results: The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01). Conclusions: In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://dc.etsu.edu/etsu-works/16684Test; https://doi.org/10.1159/000318172Test |
| DOI: | 10.1159/000318172 |
| الإتاحة: | https://doi.org/10.1159/000318172Test https://dc.etsu.edu/etsu-works/16684Test |
| رقم الانضمام: | edsbas.95A3C611 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000318172 |
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