دورية أكاديمية
Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume
| العنوان: | Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume |
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| المؤلفون: | Dalwani, Manish S., McMahon, Mary Agnes, Mikulich-Gilbertson, Susan K., Young, Susan E., Regner, Michael F., Raymond, Kristen M., McWilliams, Shannon K., Banich, Marie T., Tanabe, Jody L., Crowley, Thomas J., Sakai, Joseph T. |
| بيانات النشر: | University of Colorado Anschutz Medical Campus. Strauss Health Sciences Library PLoS ONE |
| سنة النشر: | 2015 |
| المجموعة: | Digital Collections of Colorado (Colorado State University) |
| مصطلحات موضوعية: | Adolescent, Female, Substance-Related Disorders, Conduct Disorder, Gray Matter |
| جغرافية الموضوع: | Aurora (Colo.) |
| الوصف: | Includes bibliographic references. ; OBJECTIVE: Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages. Hypotheses: Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex), conflict processing (i.e., anterior cingulate), valuation of expected outcomes (i.e., medial orbitofrontal cortex) and the dopamine reward system (i.e. striatum). METHODS: We conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years) with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM) and voxel-based morphometric (VBM8) toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p<0.05, corrected for multiple comparisons at whole-brain cluster-level threshold. RESULTS: Female adolescents with severe substance and conduct problems compared to controls showed significantly less gray matter volume in right dorsolateral prefrontal cortex, left ventrolateral prefrontal cortex, medial orbitofrontal cortex, anterior cingulate, bilateral somatosensory cortex, left suprabarginal byrus, and bilateral angular gyrus. Considering the entire brain, patients had 9.5% less overall gray matter volume compared to controls. CONCLUSIONS: Female adolescents with severe substance and conduct problems in comparison to similarly aged female healthy controls showed substantially lower gray matter volume in brain regions involved in ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Print #M123. Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. 22 May 2015; Health Sciences Library Photograph Collection and Special Collections, University of Colorado Anschutz Medical Campus; Publications.; Dalwani, Manish S., McMahon, Mary Agnes, Mikulich-Gilbertson, Susan K., Young, Susan E., Regner, Michael F., Raymond, Kristen M., McWilliams, Shannon K., Banich, Marie T., Tanabe, Jody L., Crowley, Thomas J., Sakai, Joseph T., Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. PLoS ONE 10(5): e0126368. doi:10.1371/journal.pone.0126368; http://hdl.handle.net/10968/1160Test; http://dx.doi.org/doi:10.1371/journal.pone.0126368Test |
| DOI: | 10.1371/journal.pone.0126368 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0126368Test http://hdl.handle.net/10968/1160Test |
| حقوق: | Copyright of the original work is retained by the author(s). This article was created with the support of the Open Access Fund Program, formerly available through the Strauss Health Sciences Library, an initiative that helped to finance the author processing fees of OA journals. ; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.7ACA2C9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0126368 |
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