دورية أكاديمية
أعرض في EDS

Prevalence of Hypertension in Children with Early-Stage ADPKD

التفاصيل البيبلوغرافية
العنوان: Prevalence of Hypertension in Children with Early-Stage ADPKD
المؤلفون: Massella, Laura, Mekahli, Djalila, Paripović, DuÅ¡an, Prikhodina, Larisa, Godefroid, Nathalie, Niemirska, Anna, AÄŸbaÅŸ, AyÅŸe, Kalicka, Karolina, Jankauskiene, Augustina, Mizerska-Wasiak, Malgorzata, Afonso, Alberto Caldas, Salomon, Rémi, Deschênes, Georges, Ariceta, Gema, Özçakar, Z. Birsin, Teixeira, Ana, Duzova, Ali, Harambat, Jérôme, Seeman, Tomáš, HrÄková, Gabriela, Lungu, Adrian Catalin, Papizh, Svetlana, Peco-Antic, Amira, De Rechter, Stéphanie, Giordano, Ugo, Kirchner, Marietta, Lutz, Teresa, Schaefer, Franz, Devuyst, Olivier, Wühl, Elke, Emma, Francesco
المساهمون: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de pédiatrie générale
المصدر: Clinical Journal of the American Society of Nephrology, Vol. 13, no. 6, p. 874-883 (2018)
بيانات النشر: American Society of Nephrology (ASN)
سنة النشر: 2018
المجموعة: DIAL@UCL (Université catholique de Louvain)
مصطلحات موضوعية: ABPM, Ambulatory Blood Pressure Monitoring, Antihypertensive Agents, Autosomal Dominant Polycystic Kidney Disease, Blood Pressure Determination, Blood Pressure Monitoring, Ambulatory, Child, Cysts, Humans, Logistic Models, Polycystic Kidney, Autosomal Dominant, Prevalence, Retrospective Studies, Rhythm Analysis, Blood pressure, Hypertension, Kidney, Pediatrics
الوصف: BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected. RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1555-9041
1555-905X
العلاقة: boreal:198186; http://hdl.handle.net/2078.1/198186Test; info:pmid/29674338; urn:ISSN:1555-9041; urn:EISSN:1555-905X
DOI: 10.2215/cjn.11401017
الإتاحة: https://doi.org/10.2215/cjn.11401017Test
http://hdl.handle.net/2078.1/198186Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.A5389939
قاعدة البيانات: BASE
الوصف
تدمد:15559041
1555905X
DOI:10.2215/cjn.11401017