دورية أكاديمية
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
| العنوان: | A roadmap for interpreting (13)C metabolite labeling patterns from cells. |
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| المؤلفون: | Buescher, Joerg M, Antoniewicz, Maciek R, Boros, Laszlo G, Burgess, Shawn C, Brunengraber, Henri, Clish, Clary B, DeBerardinis, Ralph J, Feron, Olivier, Frezza, Christian, Ghesquiere, Bart, Gottlieb, Eyal, Hiller, Karsten, Jones, Russell G, Kamphorst, Jurre J, Kibbey, Richard G, Kimmelman, Alec C, Locasale, Jason W, Lunt, Sophia Y, Maddocks, Oliver Dk, Malloy, Craig, Metallo, Christian M, Meuillet, Emmanuelle J, Munger, Joshua, Nöh, Katharina, Rabinowitz, Joshua D, Ralser, Markus, Sauer, Uwe, Stephanopoulos, Gregory, St-Pierre, Julie, Tennant, Daniel A, Wittmann, Christoph, Vander Heiden, Matthew G, Vazquez, Alexei, Vousden, Karen, Young, Jamey D, Zamboni, Nicola, Fendt, Sarah-Maria |
| المساهمون: | UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique |
| المصدر: | Current Opinion in Biotechnology, Vol. 34, p. 189-201 (2015) |
| بيانات النشر: | Elsevier Ltd. |
| سنة النشر: | 2015 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| الوصف: | Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although less information-rich than quantitative (13)C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. Here, we review selected key issues in interpreting (13)C metabolite labeling patterns, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0958-1669 1879-0429 |
| العلاقة: | boreal:157273; http://hdl.handle.net/2078.1/157273Test; info:pmid/25731751; urn:ISSN:0958-1669; urn:EISSN:1879-0429 |
| DOI: | 10.1016/j.copbio.2015.02.003 |
| الإتاحة: | https://doi.org/10.1016/j.copbio.2015.02.003Test http://hdl.handle.net/2078.1/157273Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.CD1F3277 |
| قاعدة البيانات: | BASE |
| تدمد: | 09581669 18790429 |
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| DOI: | 10.1016/j.copbio.2015.02.003 |