دورية أكاديمية
Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.
| العنوان: | Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study. |
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| المؤلفون: | Medas, Fabio, Dobrinja, Chiara, Al-Suhaimi, Ebtesam Abdullah, Altmeier, Julia, Anajar, Said, Arikan, Akif Enes, Azaryan, Irina, Bains, Lovenish, Basili, Giancarlo, Bolukbasi, Hakan, Bononi, Marco, Borumandi, Farzad, Bozan, Mehmet BuÄŸra, Brenta, Gabriela, Brunaud, Laurent, Brunner, Maximilian, Buemi, Antoine, THYCOVID Collaboration Group, Devresse, Arnaud, Burlacu, Maria Cristina, Mourad, Michel |
| المساهمون: | UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service d'endocrinologie et de nutrition |
| المصدر: | The lancet. Diabetes & endocrinology, Vol. 11, no. 6, p. 402-413 (2023) |
| بيانات النشر: | The Lancet, Diabetes & Endocrinology |
| سنة النشر: | 2023 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| الوصف: | BACKGROUND: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. METHODS: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. FINDINGS: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2213-8587 2213-8595 |
| العلاقة: | boreal:274605; http://hdl.handle.net/2078.1/274605Test; info:pmid/37127041; urn:ISSN:2213-8587; urn:EISSN:2213-8595 |
| DOI: | 10.1016/S2213-8587(23)00094-3 |
| الإتاحة: | https://doi.org/10.1016/S2213-8587Test(23)00094-3 http://hdl.handle.net/2078.1/274605Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.82D52779 |
| قاعدة البيانات: | BASE |
| تدمد: | 22138587 22138595 |
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| DOI: | 10.1016/S2213-8587(23)00094-3 |