دورية أكاديمية
Effect of interferon-a treatment on [68Ga-DOTA,Tyr3,Thre8] octreotide uptake in CA20948 tumors: A small-animal PET study
| العنوان: | Effect of interferon-a treatment on [68Ga-DOTA,Tyr3,Thre8] octreotide uptake in CA20948 tumors: A small-animal PET study |
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| المؤلفون: | Hanin, François-Xavier, Pauwels, S., Bol, Anne, Melis, M., Breeman, W., De Jong, M., Jamar, F. |
| المساهمون: | UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire |
| المصدر: | The Journal of Nuclear Medicine, Vol. 52, no. 4, p. 580-585 (2011) |
| بيانات النشر: | Society of Nuclear Medicine |
| سنة النشر: | 2011 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | 68Ga-DOTATATE, Alpha interferon, Animal model, Neuroendocrine tumor, Small-animal PE.T |
| الوصف: | In peptide receptor radionuclide therapy of neuroendocrine tumors, improvements have been made by increasing the affinity for receptors and by protecting critical organs (e.g., kidneys). However, tumor parameters involved in radiopeptide uptake are still under investigation. Interferon-a (IFNa) is used as biotherapy for neuroendocrine tumors. Several mechanisms of action are described, but the potential effect of IFNa on tumor uptake of labeled peptide has not been studied in vivo yet. Methods: Twenty-six male CA20948 tumor-bearing Lewis rats were imaged before and during IFNa treatment using quantitative small-animal PET with [68Ga-DOTA,Tyr3,Thre 8]octreotide. Imaging was performed at days 0, 3, and 7. Animals were divided into 3 groups according to the treatment: Control (injected daily with saline), half (4 d of IFNa treatment from day 0 to day 3, then saline), and full (7 d of IFNa). A daily dose of IFNa (1.5 mIU) was administered subcutaneously. Quantitative PET results are expressed as percentage injected dose per cm3 and normalized to baseline (day 0) values. Tumor size was monitored by PET and caliper measurements. Results: Gross tumor uptake and tumor volumes increased in all groups over the 7-d period. On day 3, mean±SD ratios to day 0 were 1.2±0.2, 1.3±0.5, and 1.2±0.4, respectively, for control, half, and full groups. On day 7, respective values were 1.1±0.2, 1.3±0.6, and 1.5±0.4. At day 3, a comparison among groups showed no statistically significant difference. At day 7, the full group showed a significantly higher ratio in activity concentration than the control group (P = 0.021). A good correlation was found between tumor volumes assessed by small-animal PET and caliper measurements (R = 0.89, P<0.0001). Conclusion: As expected, over a period of 7 d, both tumor volumes and radiopeptide uptake increased in all animals. However, the activity concentration increased significantly more at day 7 in animals treated for 7 d with IFNα, compared with controls. This is the first, to our ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0161-5505 1535-5667 |
| العلاقة: | boreal:123399; http://hdl.handle.net/2078/123399Test; urn:ISSN:0161-5505; urn:EISSN:1535-5667 |
| DOI: | 10.2967/jnumed.110.084152 |
| الإتاحة: | https://doi.org/10.2967/jnumed.110.084152Test http://hdl.handle.net/2078/123399Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8FC9D797 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01615505 15355667 |
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| DOI: | 10.2967/jnumed.110.084152 |