دورية أكاديمية
An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.
| العنوان: | An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. |
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| المؤلفون: | Lourenço, Andre P, Leite-Moreira, Adelino F, Balligand, Jean-Luc, Bauersachs, Johann, Dawson, Dana, de Boer, Rudolf A, de Windt, Leon J, Falcão-Pires, Inês, Fontes-Carvalho, Ricardo, Franz, Stefan, Giacca, Mauro, Hilfiker-Kleiner, Denise, Hirsch, Emilio, Maack, Christoph, Mayr, Manuel, Pieske, Burkert, Thum, Thomas, Tocchetti, Carlo G, Brutsaert, Dirk L, Heymans, Stephane |
| المساهمون: | UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale |
| المصدر: | European Journal of Heart Failure, Vol. 20, no. 2, p. 216-227 (2018) |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2018 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | Animal models, Experimental evaluation, Heart failure with preserved ejection fraction, Molecular biology, Myocardial function |
| الوصف: | As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long-term clinical manifestations. We will revise recent advances in animal model development, experimental set-ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher-order inter-organ and inter-cell communication to achieve a full systems biology perspective of HFpEF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1388-9842 1879-0844 |
| العلاقة: | boreal:190014; http://hdl.handle.net/2078.1/190014Test; info:pmid/29148148; urn:ISSN:1388-9842; urn:EISSN:1879-0844 |
| DOI: | 10.1002/ejhf.1059 |
| الإتاحة: | https://doi.org/10.1002/ejhf.1059Test http://hdl.handle.net/2078.1/190014Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5E820184 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13889842 18790844 |
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| DOI: | 10.1002/ejhf.1059 |