دورية أكاديمية
Human equilibrative nucleoside transporter 1 (hENT1) expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma
العنوان: | Human equilibrative nucleoside transporter 1 (hENT1) expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma |
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المؤلفون: | Borbath, Ivan, Verbrugghe, L, Lai, Raymond, Gigot, Jean-François, Humblet, Yves, Piessevaux, Hubert, Sempoux, Christine |
المساهمون: | UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Service d'anatomie pathologique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale |
المصدر: | European Journal of Cancer, Vol. 48, no. 7, p. 990-996 (2012) |
بيانات النشر: | Pergamon |
سنة النشر: | 2012 |
المجموعة: | DIAL@UCL (Université catholique de Louvain) |
مصطلحات موضوعية: | Adult, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Treatment Outcome, Aged, 80 and over, Antimetabolites, Antineoplastic, Bile Duct Neoplasms, Cholangiocarcinoma, Deoxycytidine, Disease-Free Survival, Equilibrative Nucleoside Transporter 1 |
الوصف: | BACKGROUND: Cholangiocarcinoma (CC) is a rare cancer of the liver. Surgery offers the only chance for cure. When surgery is unfeasible, chemotherapy is the backbone of treatment. The combined administration of cisplatin and gemcitabine is considered standard of care. Human equilibrative nucleoside transporter 1 (hENT1) is the major transporter responsible for gemcitabine uptake into cells. hENT1 expression is associated with an increased survival for patients receiving gemcitabine after pancreatic cancer surgery, suggesting that hENT1 is predictive of response to gemcitabine. AIM: To determine whether there is a correlation between the expression of hENT1 and disease outcome in CC. METHODS: A retrospective study on 43 patients treated at our centre with a locally advanced or metastatic CC, who received first line treatment with gemcitabine, was performed. RESULTS: For the whole population, median Progression Free Survival (PFS) and overall survival (OS) were 4.0 (95% Confidence Interval 2.7-5.3 months) and 10.0 months (95%CI 6.8-13.2 months), respectively. From the 26 samples available for hENT1 staining, 18 (69%) and 8 (31%) patients had high and low hENT1 immunostaining, respectively. The median PFS were 2.0 versus 6.0 months for low versus high staining respectively (p = 0.012). The median OS were 5.0 versus 11.0 months for low versus high staining, respectively (p = 0.036). On multivariate analysis, hENT1 expression was the single independent predictive factor associated with prolonged PFS (HR 0.35, p = 0.023) and OS (HR 0.41, p = 0.046). CONCLUSION: In this study we show the potential of hENT1 expression as a predictor of outcome in CC treated with gemcitabine. Larger studies are necessary to confirm these promising results. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 0959-8049 1879-0852 |
العلاقة: | boreal:117007; http://hdl.handle.net/2078.1/117007Test; info:pmid/22137164; urn:ISSN:0959-8049; urn:EISSN:1879-0852 |
DOI: | 10.1016/j.ejca.2011.11.006 |
الإتاحة: | https://doi.org/10.1016/j.ejca.2011.11.006Test http://hdl.handle.net/2078.1/117007Test |
حقوق: | info:eu-repo/semantics/restrictedAccess |
رقم الانضمام: | edsbas.73371207 |
قاعدة البيانات: | BASE |
تدمد: | 09598049 18790852 |
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DOI: | 10.1016/j.ejca.2011.11.006 |