دورية أكاديمية
Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans
| العنوان: | Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans |
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| المؤلفون: | Hwang, Wooseon, Artan, Murat, Seo, Mihwa, Lee, Dongyeop, Nam, Hong Gil, Lee, Seung-Jae V. |
| بيانات النشر: | Wiley Blackwell |
| سنة النشر: | 2015 |
| المجموعة: | DGIST Scholar (Daegu Gyeongbuk Institute of Science & Technology) |
| مصطلحات موضوعية: | aging, C. elegans, elc-1, hypoxia-inducible factor 1, protein homeostasis, Amino ACID Sequence, Article, CAENORHABDITIS-ELEGANS, Caenorhabditis Elegans, COMPLEX, Controlled Study, ELONGATION, Elongin C, Genetic Association, GENOME, HYPOXIA-INDUCIBLE FACTOR, Hypoxia-Inducible Factor-1, INTEGRATIVE ANALYSIS, LIFE-SPAN, Lifespan, LONGEVITY, Mitochondrial Gene, Nonhuman, Priority Journal, Protein Degradation, Protein Synthesis Inhibition, Regulatory Mechanism, RESPIRATION, RNA Interference, Transcription Elongation Factor |
| الوصف: | The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF-1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that elc-1 RNA interference increased lifespan and protein homeostasis by upregulating HIF-1. The roles of elongin C and HIF-1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF-1 in complex metazoans. © 2015 The Anatomical Society and John Wiley & Sons Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1474-9718 |
| العلاقة: | http://hdl.handle.net/20.500.11750/1652Test; 2-s2.0-84954404673; Aging Cell, v.14, no.6, pp.995 - 1002 |
| DOI: | 10.1111/acel.12390 |
| الإتاحة: | https://doi.org/20.500.11750/1652Test https://doi.org/10.1111/acel.12390Test https://hdl.handle.net/20.500.11750/1652Test |
| رقم الانضمام: | edsbas.DA905175 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14749718 |
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| DOI: | 10.1111/acel.12390 |