دورية أكاديمية
Effects of L-2-oxоthiazolidine-4-carboxylic acid on the lung antioxidant defense system in an asthma mouse model
| العنوان: | Effects of L-2-oxоthiazolidine-4-carboxylic acid on the lung antioxidant defense system in an asthma mouse model |
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| المؤلفون: | TERZIEV, Lyudmil GEORGIEV, SHOPOVA, Veneta LYUBENOVA, DANCHEVA, Violeta YORDANOVA, STAVREVA, Galya TZVETANOVA, STOYANOVA, Angelina MILCHEVA |
| المصدر: | Volume: 42, Issue: 5 901-905 ; 1300-0144 ; 1303-6165 ; Turkish Journal of Medical Sciences |
| بيانات النشر: | TÜBİTAK TUBITAK |
| سنة النشر: | 2012 |
| المجموعة: | DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: | Key words: Asthma,L-2-oхоthiazolidine-4-carboxylic acid,lung antioxidant defense system |
| الوصف: | We aim ed to study the effect of a glutathione precursor, L-2-oxothiazolidine-4-carboxylic acid (OTCA), on the lung antioxidant defense system in an animal asthma model. Materials and methods: The study was carried out on 24 female C57BL/6 mice. The mice were divided into 4 treatment groups: group 1 - control group; group 2 - injected with ovalbumin (OVA) and given an OVA inhalant; group 3 - treated with OTCA and phosphate-buffered saline inhalant; and group 4 -injected with OVA and OTCA and given an OVA inhalant. Under sodium pentobarbital anesthesia the animals were killed by exsanguination 48 h after the last inhalation to obtain a lung homogenate. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GP) and the content of nonprotein sulfhydryl (NPSH) groups in lung homogenate were investigated. Results: OVA decreased the activities of SOD (P = 0.007), CAT (P = 0.004), and GP (P = 0.05) and the NPSH content (P = 0.0008) in the lung homogenate compared with the control animals. Treatment with OVA and OTCA (group 4) resulted in a significant increase in the activities of CAT (P = 0.01) and GP (P = 0.05) and the NPSH content (P = 0.002) compared to the OVA group (group 2). Conclusion: OTCA (160 mg/kg) restored the activities of basic enzymes in the lung antioxidant defense system in an OVA-induced asthma mouse model 48 h after the last nebulization. ; We aim ed to study the effect of a glutathione precursor, L-2-oxothiazolidine-4-carboxylic acid (OTCA), on the lung antioxidant defense system in an animal asthma model. Materials and methods: The study was carried out on 24 female C57BL/6 mice. The mice were divided into 4 treatment groups: group 1 - control group; group 2 - injected with ovalbumin (OVA) and given an OVA inhalant; group 3 - treated with OTCA and phosphate-buffered saline inhalant; and group 4 -injected with OVA and OTCA and given an OVA inhalant. Under sodium pentobarbital anesthesia the animals were killed by exsanguination 48 h after the last inhalation to ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Turkish |
| العلاقة: | https://dergipark.org.tr/tr/download/article-file/128477Test; https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12296/147064Test |
| الإتاحة: | https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12296/147064Test |
| رقم الانضمام: | edsbas.B735823F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |