دورية أكاديمية
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. ...
| العنوان: | Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. ... |
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| المؤلفون: | Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R, Xu, Cheng-Jian, Vives-Usano, Marta, Rezwan, Faisal I, Felix, Janine F, Ward, James M, Guan, Weihua, Richmond, Rebecca C, Brody, Jennifer A, Küpers, Leanne K, Baïz, Nour, Håberg, Siri E, Smith, Jennifer A, Reese, Sarah E, Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A, Xu, Tao, Reynolds, Lindsay M, Just, Allan C, Mandaviya, Pooja R, Ghantous, Akram, Bennett, Brian D, Wang, Tianyuan, Consortium, The Bios, Bakulski, Kelly M, Melen, Erik, Zhao, Shanshan, Jin, Jianping, Herceg, Zdenko, Meurs, Joyce Van, Taylor, Jack A, Baccarelli, Andrea A, Murphy, Susan K, Liu, Yongmei, Munthe-Kaas, Monica Cheng, Deary, Ian J, Nystad, Wenche, Waldenberger, Melanie, Annesi-Maesano, Isabella, Conneely, Karen, Jaddoe, Vincent Wv, Arnett, Donna, Snieder, Harold, Kardia, Sharon Lr, Relton, Caroline L, Ong, Ken K |
| بيانات النشر: | Informa UK Limited |
| سنة النشر: | 2019 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | cigarette smoking, epigenetics, infant, maternal exposure, methylation, Adult, Cohort Studies, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenomics, Female, Humans, Infant, Newborn, Maternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Tobacco Smoking |
| الوصف: | Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.17863/cam.44651 |
| الإتاحة: | https://doi.org/10.17863/cam.44651Test https://www.repository.cam.ac.uk/handle/1810/297597Test |
| حقوق: | open.access ; Creative Commons Attribution Non Commercial No Derivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0/legalcodeTest ; cc-by-nc-nd-4.0 ; http://purl.org/coar/access_right/c_abf2Test |
| رقم الانضمام: | edsbas.632C598D |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/cam.44651 |
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