دورية أكاديمية
Wnt Pathway Activation by ADP-Ribosylation
| العنوان: | Wnt Pathway Activation by ADP-Ribosylation |
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| المؤلفون: | Yang, Eungi, Tacchelly-Benites, Ofelia, Wang, Zhenghan, Randall, Michael P, Tian, Ai, Benchabane, Hassina, Freemantle, Sarah, Pikielny, Claudio, Tolwinski, Nicholas S, Lee, Ethan, Ahmed, Yashi |
| المصدر: | Dartmouth Scholarship |
| بيانات النشر: | Dartmouth Digital Commons |
| سنة النشر: | 2016 |
| المجموعة: | Dartmouth Digital Commons (Dartmouth College) |
| مصطلحات موضوعية: | beta-catenin degradation, segment polarity gene, negative regulator, signaling pathway, axin degradation, coreceptor lrp6, tumor-growth, e3 ligase, drosophila, wingless, Cell and Developmental Biology, Developmental Biology, Medicine and Health Sciences, Neoplasms |
| الوصف: | Wnt/beta-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer. Wnt stimulation induces the recruitment of the scaffold protein Axin from an inhibitory destruction complex to a stimulatory signalosome. Here we analyse the early effects of Wnt on Axin and find that the ADP-ribose polymerase Tankyrase (Tnks)-known to target Axin for proteolysis-regulates Axin's rapid transition following Wnt stimulation. We demonstrate that the pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells. ADP-ribosylation of Axin enhances its interaction with the Wnt co-receptor LRP6, an essential step in signalosome assembly. We suggest that in addition to controlling Axin levels, Tnks-dependent ADP-ribosylation promotes the reprogramming of Axin following Wnt stimulation; and propose that Tnks inhibition blocks Wnt signalling not only by increasing destruction complex activity, but also by impeding signalosome assembly. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.dartmouth.edu/facoa/389Test; https://doi.org/10.1038/ncomms11430Test |
| DOI: | 10.1038/ncomms11430 |
| الإتاحة: | https://doi.org/10.1038/ncomms11430Test https://digitalcommons.dartmouth.edu/facoa/389Test |
| رقم الانضمام: | edsbas.66F1837D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ncomms11430 |
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