دورية أكاديمية
Blood Levels of S-100 Calcium-Binding Protein B, High-Sensitivity C-Reactive Protein, and Interleukin-6 for Changes in Depressive Symptom Severity after Coronary Artery Bypass Grafting: Prospective Cohort Nested within a Randomized, Controlled Trial
| العنوان: | Blood Levels of S-100 Calcium-Binding Protein B, High-Sensitivity C-Reactive Protein, and Interleukin-6 for Changes in Depressive Symptom Severity after Coronary Artery Bypass Grafting: Prospective Cohort Nested within a Randomized, Controlled Trial |
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| المؤلفون: | Pearlman, Daniel M, Brown, Jeremiah R. R, MacKenzie, Todd A, Hernandez, Felix, Najjar, Souhel |
| المصدر: | Dartmouth Scholarship |
| بيانات النشر: | Dartmouth Digital Commons |
| سنة النشر: | 2014 |
| المجموعة: | Dartmouth Digital Commons (Dartmouth College) |
| مصطلحات موضوعية: | adult, 80 and over, biomarkers, c-reactive protein, coronary artery bypass, depression, female, humans, interleukin-6, male, middle aged, postoperative complications, prospective studies, s100 calcium binding protein beta subunit, severity of illness index, il6 protein, human, s100b protein, Cardiology, Medicine and Health Sciences, Psychiatry |
| الوصف: | Background: Cross-sectional and retrospective studies have associated major depressive disorder with glial activation and injury as well as blood–brain barrier disruption, but these associations have not been assessed prospectively. Here, we aimed to determine the relationship between changes in depressive symptom severity and in blood levels of S-100 calcium- binding protein B (S-100B), high-sensitivity C-reactive protein, and interleukin-6 following an inflammatory challenge. Methods: Fifty unselected participants were recruited from a randomized, controlled trial comparing coronary artery bypass grafting procedures performed with versus without cardiopulmonary bypass for the risk of neurocognitive decline. Depressive symptom severity was measured at baseline, discharge, and six-month follow-up using the Beck Depression Inventory II (BDI-II). The primary outcome of the present biomarker study was acute change in depressive symptom severity, defined as the intra-subject difference between baseline and discharge BDI-II scores. Blood biomarker levels were determined at baseline and 2 days postoperative. Results: Changes in S-100B levels correlated positively with acute changes in depressive symptom severity (Spearman r, 0.62; P=0.0004) and accounted for about one-fourth of their observed variance (R2, 0.23; P=0.0105). This association remained statistically significant after adjusting for baseline S-100B levels, age, weight, body-mass index, or b-blocker use, but not baseline BDI-II scores (P = 0.064). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C- reactive protein or interleukin-6 levels. Among most participants, levels of all three biomarkers were normal at baseline and markedly elevated at 2 days postoperative. Conclusions: Acute changes in depressive symptom severity were specifically associated with incremental changes in S- 100B blood levels, ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.dartmouth.edu/facoa/2564Test; https://digitalcommons.dartmouth.edu/context/facoa/article/3571/viewcontent/ptpmcrender.fcgiTest |
| DOI: | 10.1371/journal.pone.0111110 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0111110Test https://digitalcommons.dartmouth.edu/facoa/2564Test https://digitalcommons.dartmouth.edu/context/facoa/article/3571/viewcontent/ptpmcrender.fcgiTest |
| رقم الانضمام: | edsbas.56F61ACA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0111110 |
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