التفاصيل البيبلوغرافية
| العنوان: |
Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma |
| المؤلفون: |
Prior, C. (Celia), Perez-Gracia, J.L. (Jose Luis), Garcia-Donas, J. (Jesús), Rodriguez-Antona, C. (Cristina), Guruceaga, E. (Elizabeth), Esteban-Gutiérrez, E. (Emilio), Suárez, C. (Cristina), Castellano, D. (Daniel), Gonzalez-del-Alba, A. (Aránzazu), Lozano, M.D. (María Dolores), Carles, J. (Joan), Climent, M.A. (Miguel Ángel), Arranz, J.A. (Jose Ángel), Gallardo, E. (Enrique), Puente, J. (Javier), Bellmunt, J. (Joaquim), Gurpide, A. (Alfonso), Lopez-Picazo, J.M. (José M.), Gonzalez-Hernandez, A. (Alvaro), Mellado, B. (Begoña), Martinez, E. (Esther), Moreno, F. (Fernando), Font, A. (Albert), Calvo-González, A. (Alfonso) |
| بيانات النشر: |
Public Library of Science |
| سنة النشر: |
2014 |
| المجموعة: |
dadun - Depósito Académico Digital Universidad de Navarra |
| مصطلحات موضوعية: |
Tissue microRNAs, Metastatic renal, Carcinoma |
| الوصف: |
We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://hdl.handle.net/10171/35300Test |
| الإتاحة: |
https://hdl.handle.net/10171/35300Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.A83AE9F4 |
| قاعدة البيانات: |
BASE |
