رسالة جامعية
Verukotoksin u kamenoj ribi ; Verrucotoxin in stonefish
| العنوان: | Verukotoksin u kamenoj ribi ; Verrucotoxin in stonefish |
|---|---|
| المؤلفون: | Deur, Kristina |
| المساهمون: | Pavela Vrančić, Maja |
| بيانات النشر: | Sveučilište u Splitu. Sveučilišni odjel za studije mora. University of Split. University Department of Marine Studies. |
| سنة النشر: | 2018 |
| المجموعة: | Croatian Digital Theses Repository (National and University Library in Zagreb) |
| مصطلحات موضوعية: | verukotoksin, Synanceiaverrucosa, KATP kanali, Ca2+ kanali, muskarinski M3 receptor, verrucotoxin, KATP channels, Ca2+ channels, muscarinic M3 receptor, PRIRODNE ZNANOSTI. Biologija, NATURAL SCIENCES. Biology |
| الوصف: | Kamena riba (Synancea verrucosa, Bloch & Schneider, 1801) jedna je od najsmrtonosnijih riba na svijetu. Verukotoksin je osnovni sastojak otrova kamene ribe. Ubod bodlje leđne peraje uzrokuje intenzivnu bol, grčenje mišića, paralizu, sniženje krvnog tlaka, respiratorne smetnje, kardiovaskularni kolaps, a često može imati i smrtonosni ishod. Zabilježeno je da verukotoksin može modulirati Ca2+ kanale i ATP osjetljive K+ kanale (KATP)u žabljim atrijskim vlaknima inducirajući hipotenziju, a također ima i hemolitičko djelovanje. Međutim, stanični i molekularni mehanizmi toksičnosti verukotoksina, a naročito njegove kardiotoksičnosti prema srcu sisavaca, još nisu u potpunosti istraženi. Rezultati upućuju na to da verukotoksin djeluje na KATP kanale putem muskarinskih M3 receptora. Ova otkrića omogućuju bolje razumijevanje toksičnih učinaka verukotoksina iz otrova kamene ribe. ; Stonefish (Synancea verrucosa, Bloch & Schneider, 1801) is one of the deadliest fish in the world. Verrucotoxin is the main ingredient of the stonefish venom. A sting of the dorsal spine causes intensive pain, convulsions, paralysis, hypotension, respiratory distress, collapse of a cardiovascular system, and often can have a deadly outcome. It has been reported that verrucotoxin can modulate Ca2+ channels and ATP-sensitive K+(KATP)channels in frog atrial fibers inducing hypotension, and also it has hemolytic activity. However, the cellular and molecular mechanisms of verrucotoxin toxicity, especially its cardiotoxicity towards the mammalian heart, have not yet been fully investigated. The results suggest that verrucotoxin inhibits KATP channels through the muscarinic M3 receptor pathway. These findings allow us a better understanding of the toxic effects of verrucotoxin from stonefish. |
| نوع الوثيقة: | bachelor thesis |
| وصف الملف: | application/pdf |
| اللغة: | Croatian |
| العلاقة: | https://zir.nsk.hr/islandora/object/morest:280Test; https://urn.nsk.hr/urn:nbn:hr:226:713245Test; https://repozitorij.svkst.unist.hr/islandora/object/morest:280Test; https://repozitorij.svkst.unist.hr/islandora/object/morest:280/datastream/PDFTest |
| الإتاحة: | https://zir.nsk.hr/islandora/object/morest:280Test https://urn.nsk.hr/urn:nbn:hr:226:713245Test https://repozitorij.svkst.unist.hr/islandora/object/morest:280Test https://repozitorij.svkst.unist.hr/islandora/object/morest:280/datastream/PDFTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.F3B126EC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |