دورية أكاديمية
Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice
| العنوان: | Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice |
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| المؤلفون: | Orona, Nadia Soledad, Astort, Francisco, Maglione, Guillermo Alberto, Ferraro, Sebastián Ariel, Martin, Maximiliano Emanuel, Morales, Celina, Mandalunis, Patricia Mónica, Brites, Fernando Daniel, Tasat, Jose Alejandro |
| بيانات النشر: | Academic Press Inc Elsevier Science |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | EXTRAPULMONARY ORGANS, INFLAMMATION, LUNG, OXIDATIVE METABOLISM, URBAN AIR POLLUTION, https://purl.org/becyt/ford/3.3Test, https://purl.org/becyt/ford/3Test |
| الوصف: | Air particulate matter (PM) can lead to extrapulmonary adverse reactions in organs such as liver and heart either by particle translocation from the lung to the systemic circulation or by the release of lung mediators. Young BALB/c mice were intranasal instilled with 1mg/BW of Urban Air Particles from Buenos Aires or Residual Oil Fly Ash. Histopathology, oxidative metabolism and inflammation on lungs and extrapulmonary organs and the systemic response were evaluated. Lung histophatological analysis supported the rise in the number of inflammatory cells in the bronchoalveolar lavage from PM-exposed animals. Also, both PM caused recruitment of inflammatory cells in the liver and heart parenchyma and IL-6 and transaminases augmentation in serum. We have shown that despite morphochemical differences, both urban air PM altered the lung and extrapulmonary organs. Therefore, exposure to urban air PM may distress body metabolism which, in turn could lead to the development and progression of multifactorial diseases. ; Fil: Orona, Nadia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina ; Fil: Astort, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina ; Fil: Maglione, Guillermo Alberto. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina ; Fil: Ferraro, Sebastián ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0147-6513 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0147651319314514Test; http://hdl.handle.net/11336/148870Test; Orona, Nadia Soledad; Astort, Francisco; Maglione, Guillermo Alberto; Ferraro, Sebastián Ariel; Martin, Maximiliano Emanuel; et al.; Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice; Academic Press Inc Elsevier Science; Ecotoxicology and Environmental Safety; 190; 3-2020; 1-11; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1016/j.ecoenv.2019.110120Test http://hdl.handle.net/11336/148870Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/arTest/ |
| رقم الانضمام: | edsbas.7CF2C5C5 |
| قاعدة البيانات: | BASE |
| تدمد: | 01476513 |
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