دورية أكاديمية
Improved biomechanical metrics of cerebral vasospasm identified via sensitivity analysis of a 1D cerebral circulation model
| العنوان: | Improved biomechanical metrics of cerebral vasospasm identified via sensitivity analysis of a 1D cerebral circulation model |
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| المؤلفون: | Melis, A., Moura, F., Larrabide, Ignacio, Janot, K., Clayton, R. H., Narata, A.P., Marzo, A. |
| بيانات النشر: | Elsevier |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | 1D CARDIOVASCULAR MODELLING, STATISTICAL EMULATOR, GAUSSIAN PROCESS, VASOSPASM, PULSE WAVE PROPAGATION, https://purl.org/becyt/ford/1.2Test, https://purl.org/becyt/ford/1Test |
| الوصف: | Cerebral vasospasm (CVS) is a life-threatening condition that occurs in a large proportion of those affected by subarachnoid haemorrhage and stroke. CVS manifests itself as the progressive narrowing of intracranial arteries. It is usually diagnosed using Doppler ultrasound, which quantifies blood velocity changes in the affected vessels, but has low sensitivity when CVS affects the peripheral vasculature. The aim of this study was to identify alternative biomarkers that could be used to diagnose CVS. We used a 1D modelling approach to describe the properties of pulse waves that propagate through the cardiovascular system, which allowed the effects of different types of vasospasm on waveforms to be characterised at several locations within a simulated cerebral network. A sensitivity analysis empowered by the use of a Gaussian process statistical emulator was used to identify waveform features that may have strong correlations with vasospasm. We showed that the minimum rate of velocity change can be much more effective than blood velocity for stratifying typical manifestations of vasospasm and its progression. The results and methodology of this study have the potential not only to improve the diagnosis and monitoring of vasospasm, but also to be used in the diagnosis of many other cardiovascular diseases where cardiovascular waves can be decoded to provide disease characterisation. ; Fil: Melis, A. University Of Sheffield; Reino Unido ; Fil: Moura, F. Universidade Federal Do Abc; Brasil ; Fil: Larrabide, Ignacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina ; Fil: Janot, K. University Of Sheffield; Reino Unido ; Fil: Clayton, R. H. University Of Sheffield; Reino Unido ; Fil: Narata, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0021-9290 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021929019302830?via%3DihubTest; http://hdl.handle.net/11336/120326Test; Melis, A.; Moura, F.; Larrabide, Ignacio; Janot, K.; Clayton, R. H.; et al.; Improved biomechanical metrics of cerebral vasospasm identified via sensitivity analysis of a 1D cerebral circulation model; Elsevier; Journal Of Biomechanics; 90; 6-2019; 24-32; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1016/j.jbiomech.2019.04.019Test http://hdl.handle.net/11336/120326Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/arTest/ |
| رقم الانضمام: | edsbas.AE47A61B |
| قاعدة البيانات: | BASE |
| تدمد: | 00219290 |
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