دورية أكاديمية
Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated co-morbidities: a mini-review
| العنوان: | Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated co-morbidities: a mini-review |
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| المؤلفون: | Claveles Casas, Florencia Nahir, Barrera, Florencia Soledad, López, Cristofer Martín, Chacon, Inalen del Valle, Di Sciullo, Maria Paula, Ramirez, Dario, Gomez-Mejiba, Sandra Esther |
| بيانات النشر: | Medwin Publishers |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | OBESITY, ADIPOSE TISSUE INFLAMMATION, SYSTEMIC INFLAMMATION, NEUTROPHIL, MYELOPEROXIDASE, THERAPEUTIC TARGET, https://purl.org/becyt/ford/3.1Test, https://purl.org/becyt/ford/3Test |
| الوصف: | Epidemiology and experimental models have shown a close link between adipose tissue inflammation, systemic inflammation and pulmonary neutrophilic inflammation, which predispose obese patients to pulmonary diseases, obesity-associated co-morbidities and cancer. Increased content and activation of neutrophils in the lung microvasculature, resulting from peripheral activation of neutrophils, and increased adhesion of neutrophils to the lung microvasculature are important factors explaining the increased susceptibility of obese patients towards respiratory diseases and loss of insulin sensitivity. Mechanism-based therapies to break this link are urgently needed to reduce pulmonary damage in obesity, due to the growing prevalence of obesity world-wide. Current research suggests that these approaches should be focused on, one or more of the following: reduction of macrophage activation at the adipose tissue, healthy growing of adipose tissue by induction of Nrf-2, inhibition of NF-?B activation, reduction of circulating neutrophil activation, blocking adhesins/selectins, inhibition of neutrophil activation by targeting NADPH oxidase-2 activation, inhibition of myeloperoxidase activity and scavenging of hypochlorous acid. These strategies are expected to reduce adipose tissue inflammation, peripheral inflammation, pulmonary neutrophilic inflammation and obesity-associated co-morbidities. ; Fil: Claveles Casas, Florencia Nahir. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina ; Fil: Barrera, Florencia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2574-7797 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.raftpubs.com/ojpsr-pharmaceutical-science-and-research/articles/ojpsr_raft1006.phpTest; http://hdl.handle.net/11336/118731Test; Claveles Casas, Florencia Nahir; Barrera, Florencia Soledad; López, Cristofer Martín; Chacon, Inalen del Valle; Di Sciullo, Maria Paula; et al.; Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated co-morbidities: a mini-review; Medwin Publishers; Open Journal of Pharmaceutical Research; 1; 8-2019; 123-133; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.36811/ojpsr.2019.110006Test http://hdl.handle.net/11336/118731Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.AC25F81A |
| قاعدة البيانات: | BASE |
| تدمد: | 25747797 |
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