التفاصيل البيبلوغرافية
| العنوان: |
Bile Acid Biosynthesis during Liver Regeneration: Enzyme Activities of Cholesterol 7α-Hydroxylase and 3β-Hydroxy-∆5-C27-Steroid Dehydrogenase in Rats |
| المؤلفون: |
Yorio Maeda, Hidehito Nagatomo, Naoya Kuroki, Junji Nagatomo, Fujio Uchiyama, Koji Shimozono, Yoshiaki Kohno, Kazuo Chijiiwa |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.annclinlabsci.org/content/35/3/323.full.pdfTest. |
| سنة النشر: |
2004 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
liver regeneration, cholesterol 7α-hydroxylase, 3β-hydroxy-∆5-C27-steroid dehydrogenase, cytochrome P450 |
| الوصف: |
The effects of two-thirds partial hepatectomy on bile acid metabolism have not been well established. This study investigated the changes in microsomal enzymes activities during liver regeneration. The cholesterol 7α-hydroxylase (7α-hydroxylase) and 3β-hydroxy-∆5-C27-steroid dehydrogenase (3β-dehydrogenase) activities in male Wistar rats were determined using high-performance liquid chromatography (HPLC). Cytochrome P450 (P450) and cytochrome b5 (b5) levels and NADPH cytochrome c reductase activities were also determined after hepatectomy. 7α-Hydroxylase activities were not reduced on days 3, 5, or 7 compared to those of sham-operated rats, but there was a significant decrease (by 60%) of 3β-dehydrogenase activity compared to that of sham-operated groups (p <0.01) on days 3, 5, and 7 after hepatectomy. While 7α-hydroxylase activity had recovered by day 3 after hepatectomy, 3β-dehydrogenase activity had not, even on day 7. These results suggest that the mechanisms of regulation of these 2 bile acid metabolizing enzymes |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.541.9849Test; http://www.annclinlabsci.org/content/35/3/323.full.pdfTest |
| الإتاحة: |
http://www.annclinlabsci.org/content/35/3/323.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.B61C72A6 |
| قاعدة البيانات: |
BASE |
