التفاصيل البيبلوغرافية
| العنوان: |
Abstract Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins |
| المؤلفون: |
Purnima Guda A, Philip E. Bourne B, Chittibabu Guda A |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.sdsc.edu/pb/papers/guda06.pdfTest. |
| سنة النشر: |
2006 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
Voltage-gated ion channel proteins, VGC proteins, VGC motifs, Calcium channel proteins, Potassium channel proteins, Sodium channel |
| الوصف: |
Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis methods. In this study, we have used a profile-to-profile alignment method to identify several new conserved motifs specific to each transmembrane segment (TMS) of the voltage-sensing and the pore-forming modules of Ca 2+, Na +, and K + channel subfamilies. For Ca 2+ and Na +, the functional theme of motif conservation is similar in all segments while they differ with those of the K + channel proteins. Nevertheless, the conservation is strikingly similar in the S4 segment of the voltage-sensing module across all subfamilies. In each subfamily and for each TMS, we have identified conserved motifs/residues and correlated their functional significance and disease associations in human, using mutational data from the literature. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.74.2234Test; http://www.sdsc.edu/pb/papers/guda06.pdfTest |
| الإتاحة: |
http://www.sdsc.edu/pb/papers/guda06.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.F5742457 |
| قاعدة البيانات: |
BASE |
