دورية أكاديمية
Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues
| العنوان: | Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues |
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| المؤلفون: | Mohamed Jawed Ahsan, Jyotika Sharma, Monika Singh, Surender Singh Jadav, Sabina Yasmin |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://downloads.hindawi.com/journals/bmri/2014/814984.pdfTest. |
| المجموعة: | CiteSeerX |
| الوصف: | In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers cell lines. N-(2,4-Dimethylphenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-amine (4s) showed maximum activity with mean growth percent (GP) of 62.61 and was found to be the most sensitive on MDA-MB-435 (melanoma), K-562 (leukemia), T-47D (breast cancer), and HCT-15 (colon cancer) cell lines with GP of 15.43, 18.22, 34.27, and 39.77, respectively. Maximum GP was observed on MDA-MB-435 (melanoma) cell line (GP = 6.82) by compound N- (2,4-dimethylphenyl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-amine (4u). |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1072.3240Test; http://downloads.hindawi.com/journals/bmri/2014/814984.pdfTest |
| الإتاحة: | http://downloads.hindawi.com/journals/bmri/2014/814984.pdfTest |
| حقوق: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.B158A3CE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |