التفاصيل البيبلوغرافية
| العنوان: |
Early Minocycline Treatment Prevents a Decrease in Striatal Dopamine in an SIV Model of HIV-Associated Neurological Disease |
| المؤلفون: |
Kelly A. Meulendyke, Mikhail V. Pletnikov, Elizabeth L. Engle, Patrick M. Tarwater, David R. Graham, M. Christine Zink |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354017/pdf/nihms-346930.pdfTest. |
| المجموعة: |
CiteSeerX |
| الوصف: |
HIV-infected individuals, even with antiretroviral therapy, often display cognitive, behavioral and motor abnormalities and have decreased dopamine (DA) levels. Minocycline prevents encephalitis and neurodegeneration in SIV models, suggesting that it might also protect against nigrostriatal dopaminergic system dysfunction. Using an SIV/macaque model of HIV-associated CNS disease, we demonstrated that striatal levels of DA were significantly lower in macaques late in infection and that levels of the metabolite DOPAC also tended to be lower. DA levels declined more than its metabolites, indicating a dysregulation of DA production or catabolism. Minocycline treatment beginning at 12 but not 21 days postinoculation prevented striatal DA loss. DA decline was not due to direct loss of dopaminergic projections to the basal ganglia as there was no difference in tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter 2 or synaptophysin between minocycline-treated and untreated macaques. SIV-infected macaques had significantly |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.665.2423Test; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354017/pdf/nihms-346930.pdfTest |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354017/pdf/nihms-346930.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.5C091687 |
| قاعدة البيانات: |
BASE |
