التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of Immune Responses to Seasonal Infl uenza Vaccination in Healthy Volunteers in South Apulia, Italy: A Pilot Study |
| المؤلفون: |
Original Article, J Clin, Med Res, Quattrocchi Manuelaa, Lobreglio Gianbattistab, Leuzzi Gianpieroc A, De Donno Antonella |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/00/48/J_Clin_Med_Res_2011_Dec_10_3(6)_291-295.tar.gz |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
T cells, Flow cyt |
| الوصف: |
Background: The aim of our pilot study is to investigate different components of the immune response to influenza vaccination in a group of healthy volunteers. We evaluated the cellular immune response (CD4 + T lymphocytes) by flow cytometry. The humoral immune response was assessed by measuring the serum haemagglutination inhibition antibody response. Methods: Healthy adult donors (n = 18), were vaccinated with a commercially influenza virus vaccine (FLUARIX ® GlaxoSmith-Kline S.p.a. Verona, Italy), peripheral blood was drawn the same day as influenza virus vaccination and one month later in order to enumerate the antigen-specific CD4 + T lymphocytes. Hemagglutination inhibition assay was performed to enumerate the titer of neutralizing antibodies. Samples of nasal-pharyngeal secretions were taken by swabbing, from ILI (Influenza like Illness) subjects among the studied group, in order to verify influenza infections and eventually identify viruses using Real Time PCR. Results and Conclusions: Parenteral influenza vaccination results in significant increase in the CD4 + Th cell population after vaccination. The number of pre-vaccination CD4 + T cells was 0.018 [the results are presented as number of percent fluorescent cells per 10 000 Manuscript accepted for publication July 22, 2011 a |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.272.2540Test |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.ADA0BF7A |
| قاعدة البيانات: |
BASE |
