التفاصيل البيبلوغرافية
| العنوان: |
DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription |
| المؤلفون: |
Ana Sancho, Jordi Duran, Antonio García-españa, Caroline Mauvezin, Endalkachew A. Alemu, Trond Lamark, Maria J. Macias, Rob Desalle, Miriam Royo, David Sala, Javier U. Chicote, Manuel Palacín, Terje Johansen, Antonio Zorzano |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://research.amnh.org/users/desalle/pdf/Sancho.2012.PLoSONE.regulators.pdfTest. |
| المجموعة: |
CiteSeerX |
| الوصف: |
Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in metazoan species. Invertebrates harbor only one gene, DOR/Tp53inp2, and in the common ancestor of vertebrates Tp53inp1 may have arisen by gene duplication. In keeping with these data, we show that human TP53INP1 regulates autophagy and that different DOR/TP53INP2 and TP53INP1 proteins display transcriptional activity. The use of molecular evolutionary information has been instrumental to determine the regions that participate in DOR functions. DOR and TP53INP1 proteins share two highly conserved regions (region 1, aa residues 28–42; region 2, 66– 112 in human DOR). Mutation of conserved hydrophobic residues in region 1 of DOR (that are part of a nuclear export signal, NES) reduces transcriptional activity, and blocks nuclear exit and autophagic activity under autophagy-activated |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.419.5525Test; http://research.amnh.org/users/desalle/pdf/Sancho.2012.PLoSONE.regulators.pdfTest |
| الإتاحة: |
http://research.amnh.org/users/desalle/pdf/Sancho.2012.PLoSONE.regulators.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.D93F18B4 |
| قاعدة البيانات: |
BASE |
