التفاصيل البيبلوغرافية
| العنوان: |
Identification of novel peptides that stimulate human neutrophils |
| المؤلفون: |
Geon Ho Bae, Ha Young Lee, Young Su Jung, Jae Woong Shim, Sang Doo Kim, Suk-hwan Baek, Jae Young Kwon, Joon Seong Park, Yoe-sik Bae |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/21/b3/Exp_Mol_Med_2012_Feb_29_44(2)_130-137.tar.gz |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
calcium, chemotaxis, neutrophils, peptide library, peptides, receptors |
| الوصف: |
PS-SPCL, positional scanning synthetic peptide combinatorial library; PTX, pertussis toxin Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel peptides by screening a synthetic hexapeptide combinatorial library. The identified peptides GMMWAI, MMHWAM, and MMHWFM caused an increase in intracellular Ca 2+ in a concentration-dependent manner via phospholipase C activity in human neutrophils. The three peptides acted specifically on neutrophils and monocytes and not on other non-leukocytic cells. As a physiological characteristic of the peptides, we observed that the three peptides induced chemotactic migration of neutrophils as well as stimulated superoxide anion production. Studying receptor specificity, we observed that two of the peptides (GMMWAI and MMHWFM) acted on formyl peptide receptor (FPR)1 while the other peptide (MMHWAM) acted on FPR2. Since the three novel peptides were specific agonists for FPR1 or FPR2, they might be useful tools to study FPR1- or FPR2-mediated immune response and signaling. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.8226Test |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.FEFF3986 |
| قاعدة البيانات: |
BASE |
