دورية أكاديمية
Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor
| العنوان: | Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor |
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| المؤلفون: | Tu, Dom-Gene, Chang, Wen-Wei, Lin, Song-Tao, Kuo, Chun-Yu, Tsao, Yu-Tzu, Lee, Che-Hsin |
| المساهمون: | Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Nucl Med, Chia Nan Univ Pharm & Sci, Dept Food Sci & Technol, Chang Jung Christian Univ, Coll Hlth Sci, Chung Shan Med Univ, Coll Med Sci & Technol, Dept Biomed Sci, Chung Shan Med Univ Hosp, Dept Med Res, China Med Univ, Sch Med, Dept Microbiol, China Med Univ, Sch Med, Grad Inst Basic Med Sci, Taoyuan Gen Hosp, Dept Med, Natl Sun Yat Sen Univ, Dept Biol Sci |
| بيانات النشر: | Impact Journals Llc |
| سنة النشر: | 2016 |
| المجموعة: | Chia Nan University of Pharmacy & Science Institutional Repository (CHNAIR) |
| مصطلحات موضوعية: | Salmonella, tumor-targeting, angiogenesis, hypoxia-inducible factor-1 alpha, vascular endothelial growth factor, efficacy |
| الوصف: | Salmonella is a Gram-negative, facultative anaerobe that is a common cause of host intestinal infections. Salmonella grows under aerobic and anaerobic conditions, and it has been proven capable of inhibiting tumor growth. However, the molecular mechanism by which Salmonella inhibits tumor growth is still unclear. Angiogenesis plays an important role in the development and progression of tumors. We investigated the antitumor effect of Salmonella in a syngeneic murine tumor model. Hypoxia-inducible factor-1 (HIF-1) a plays a significant role in tumor angiogenesis. We examined the molecular mechanism by which Salmonella regulated vascular endothelial growth factor (VEGF), which is an important angiogenic factor. The expression of VEGF in tumor cells was decreased by treatment with Salmonella. The conditioned medium from Salmonella-treated cells inhibited the proliferation of endothelial cells. Salmonella inhibited the expression of HIF-1 alpha as well as downregulated its upstream signal mediator protein kinase B (AKT). Salmonella significantly inhibited tumor growth in vivo, and immunohistochemical studies of the tumors revealed decreased intratumoral microvessel density. These results suggest that Salmonella therapy, which exerts anti-angiogenic activities, represents a promising strategy for the treatment of tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 106 bytes; text/html |
| اللغة: | English |
| تدمد: | 1949-2553 |
| العلاقة: | Oncotarget, v.7 n.25, pp.37513-37523; https://ir.cnu.edu.tw/handle/310902800/30902Test; https://ir.cnu.edu.tw/bitstream/310902800/30902/-1/30902.pdfTest; https://ir.cnu.edu.tw/bitstream/310902800/30902/1/index.htmlTest |
| DOI: | 10.18632/oncotarget.7038 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.7038Test https://ir.cnu.edu.tw/handle/310902800/30902Test https://ir.cnu.edu.tw/bitstream/310902800/30902/-1/30902.pdfTest https://ir.cnu.edu.tw/bitstream/310902800/30902/1/index.htmlTest |
| رقم الانضمام: | edsbas.F5DFD687 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19492553 |
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| DOI: | 10.18632/oncotarget.7038 |