دورية أكاديمية
Similar Levels of X-linked and Autosomal Nucleotide Variation in African and Non-African populations of Drosophila melanogaster
| العنوان: | Similar Levels of X-linked and Autosomal Nucleotide Variation in African and Non-African populations of Drosophila melanogaster |
|---|---|
| المؤلفون: | Singh, Nadia D., Macpherson, J. Michael, Jensen, Jeffrey D., Petrov, Dmitri A. |
| المصدر: | Biology, Chemistry, and Environmental Sciences Faculty Articles and Research |
| بيانات النشر: | Chapman University Digital Commons |
| سنة النشر: | 2007 |
| المجموعة: | Chapman University Digital Commons |
| مصطلحات موضوعية: | Insect Genes, X-Linked Genes, Genetic Variation, Drosophila Melanogaster, Animals, Base Sequence, Female, Male, Models, Genetic, Polymorphism, Single Nucleotide, Sequence Alignment, Species Specificity, Genetics, Other Animal Sciences, Other Genetics and Genomics, Zoology |
| الوصف: | Background: Levels of molecular diversity in Drosophila have repeatedly been shown to be higher in ancestral, African populations than in derived, non-African populations. This pattern holds for both coding and noncoding regions for a variety of molecular markers including single nucleotide polymorphisms and microsatellites. Comparisons of X-linked and autosomal diversity have yielded results largely dependent on population of origin. Results: In an attempt to further elucidate patterns of sequence diversity in Drosophila melanogaster, we studied nucleotide variation at putatively nonfunctional X-linked and autosomal loci in sub-Saharan African and North American strains of D. melanogaster. We combine our experimental results with data from previous studies of molecular polymorphism in this species. We confirm that levels of diversity are consistently higher in African versus North American strains. The relative reduction of diversity for X-linked and autosomal loci in the derived, North American strains depends heavily on the studied loci. While the compiled dataset, comprised primarily of regions within or in close proximity to genes, shows a much more severe reduction of diversity on the X chromosome compared to autosomes in derived strains, the dataset consisting of intergenic loci located far from genes shows very similar reductions of diversities for X-linked and autosomal loci in derived strains. In addition, levels of diversity at X-linked and autosomal loci in the presumably ancestral African population are more similar than expected under an assumption of neutrality and equal numbers of breeding males and females. Conclusion: We show that simple demographic scenarios under assumptions of neutral theory cannot explain all of the observed patterns of molecular diversity. We suggest that the simplest model is a population bottleneck that retains an ancestral female-biased sex ratio, coupled with higher rates of positive selection at X-linked loci in close proximity to genes specifically in derived, ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.chapman.edu/sees_articles/31Test; https://digitalcommons.chapman.edu/cgi/viewcontent.cgi?article=1031&context=sees_articlesTest |
| الإتاحة: | https://digitalcommons.chapman.edu/sees_articles/31Test https://digitalcommons.chapman.edu/cgi/viewcontent.cgi?article=1031&context=sees_articlesTest |
| حقوق: | The authors ; http://creativecommons.org/licenses/by/2.0Test/ |
| رقم الانضمام: | edsbas.5BBFEB6F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |