دورية أكاديمية
Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya
| العنوان: | Microsatellite typing reveals strong genetic structure of Schistosoma mansoni from localities in Kenya |
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| المؤلفون: | Agola, L.E., Mburu, D.N., DeJong, R.J., Mungai, B.N., Muluvi, G.M., Njagi, E.N.M., Loker, E.S., Mkoji, G.M. |
| المصدر: | Infection, Genetics and Evolution |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | CGIAR CGSpace (Consultative Group on International Agricultural Research) |
| مصطلحات موضوعية: | schistosoma mansoni, microsatellites, biodiversity, population structure, schistosomiasis |
| الوصف: | Genetic diversity and population structure of seven populations of Schistosoma mansoni sampled in Kenya were assessed using five microsatellite markers. The mean number of alleles per locus, expected heterozygosity in Hardy-Weinberg equilibrium and pairwise FST values ranged from 5.2 to 10.7, 0.5-0.8 and 3.6-27.3%, respectively. These data reveal that S. mansoni populations in Kenyan have relatively high levels of genetic diversity and is significantly differentiated. Our data combined with information on biogeography support the hypothesis that the strong genetic structure in Kenyan schistosomes is as a result of limited gene flow and large population sizes. Resistance to anthelminthics has not been reported among the Kenyan schistosomes, we hypothesize that this is probably due to the very little gene flow among populations, thereby limiting opportunities for the spread of rare alleles that might confer resistance to the drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | p. 484-490 |
| اللغة: | English |
| تدمد: | 1567-1348 |
| العلاقة: | Infection, Genetics and Evolution;6(6): 484-490; https://hdl.handle.net/10568/28770Test; https://doi.org/10.1016/j.meegid.2006.03.002Test |
| DOI: | 10.1016/j.meegid.2006.03.002 |
| الإتاحة: | https://doi.org/10.1016/j.meegid.2006.03.002Test https://hdl.handle.net/10568/28770Test |
| حقوق: | Copyrighted; all rights reserved ; Limited Access |
| رقم الانضمام: | edsbas.82D2D473 |
| قاعدة البيانات: | BASE |
| تدمد: | 15671348 |
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| DOI: | 10.1016/j.meegid.2006.03.002 |