التفاصيل البيبلوغرافية
| العنوان: |
Carbapenem Resistance in Klebsiella pneumoniae Not Detected by Automated Susceptibility Testing ; Emerg Infect Dis |
| المساهمون: |
Tenover, Fred C., Kalsi, Rajinder K., Williams, Portia P., Carey, Roberta B., Stocker, Sheila, Lonsway, David, Rasheed, J. Kamile, Biddle, James W., McGowan, John E., Hanna, Bruce |
| المصدر: |
Emerg Infect Dis. 12(8):1209-1213. |
| المجموعة: |
CDC Stacks (Centers for Disease Control and Prevention) |
| مصطلحات موضوعية: |
Research, carbapenem, imipenem, meropenem, susceptibility testing, Klebsiella, beta-lactamase, carbapenemase, Anti-Bacterial Agents, Automation, Carbapenems, Drug Resistance, Bacterial, Humans, Klebsiella pneumoniae, Microbial Sensitivity Tests, Reference Standards, Thienamycins |
| الوصف: |
Detecting beta-lactamase-mediated carbapenem resistance among Klebsiella pneumoniae isolates and other Enterobacteriaceae is an emerging problem. In this study, 15 blaKPC-positive Klebsiella pneumoniae that showed discrepant results for imipenem and meropenem from 4 New York City hospitals were characterized by isoelectric focusing; broth microdilution (BMD); disk diffusion (DD); and MicroScan, Phoenix, Sensititre, VITEK, and VITEK 2 automated systems. All 15 isolates were either intermediate or resistant to imipenem and meropenem by BMD; 1 was susceptible to imipenem by DD. MicroScan and Phoenix reported 1 (6.7%) and 2 (13.3%) isolates, respectively, as imipenem susceptible. VITEK and VITEK 2 reported 10 (67%) and 5 (33%) isolates, respectively, as imipenem susceptible. By Sensititre, 13 (87%) isolates were susceptible to imipenem, and 12 (80%) were susceptible to meropenem. The VITEK 2 Advanced Expert System changed 2 imipenem MIC results from >16 ?g/mL to <2 ?g/mL but kept the interpretation as resistant. The recognition of carbapenem-resistant K. pneumoniae continues to challenge automated susceptibility systems. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
unknown |
| العلاقة: |
http://stacks.cdc.gov/view/cdc/7927Test/ |
| الإتاحة: |
http://stacks.cdc.gov/view/cdc/7927Test/ |
| رقم الانضمام: |
edsbas.3A71C707 |
| قاعدة البيانات: |
BASE |
