دورية أكاديمية
Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex
| العنوان: | Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex |
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| المؤلفون: | Xing, Lei, Larsen, Rylan S., Bjorklund, George Reed, Li, Xiaoyan, Wu, Yaohong, Philpot, Benjamin D., Snider, William D., Newbern, Jason M. |
| المصدر: | ELife, 5 |
| سنة النشر: | 2016 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Neurogenesis, Neuroscience, Research Article, Mouse, excitatory neuron, Neocortex, corticospinal, excitability, Neurons, Gene Expression Regulation, Transgenic, Cell Differentiation, kinase, Developmental Biology and Stem Cells, Animals, MAP Kinase Signaling System, axon, Mice, Developmental |
| الوصف: | Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neurons. Our data reveal a critical requirement for ERK/MAPK signaling in the morphological development and survival of large Ctip2+ neurons in layer 5. Loss of Map2k1/2 (Mek1/2) led to deficits in corticospinal tract formation and subsequent corticospinal neuron apoptosis. ERK/MAPK hyperactivation also led to reduced corticospinal axon elongation, but was associated with enhanced arborization. ERK/MAPK signaling was dispensable for axonal outgrowth of layer 2/3 callosal neurons. However, Map2k1/2 deletion led to reduced expression of Arc and enhanced intrinsic excitability in both layers 2/3 and 5, in addition to imbalanced synaptic excitation and inhibition. These data demonstrate selective requirements for ERK/MAPK signaling in layer 5 circuit development and general effects on cortical pyramidal neuron excitability. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/40qe-9v91Test; https://cdr.lib.unc.edu/downloads/j3860c83f?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/j3860c83fTest |
| DOI: | 10.17615/40qe-9v91 |
| الإتاحة: | https://doi.org/10.17615/40qe-9v91Test https://cdr.lib.unc.edu/downloads/j3860c83f?file=thumbnailTest https://cdr.lib.unc.edu/downloads/j3860c83fTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.C3E53EE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/40qe-9v91 |
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