رسالة جامعية
Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis
| العنوان: | Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis |
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| المؤلفون: | Xia Sheng |
| المساهمون: | Kun Lu |
| سنة النشر: | 2021 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| الوصف: | Chronic arsenic exposure perturbs mammalian metabolome. Gut microbiota regulates the host metabolic homeostasis, and previous studies have demonstrated that arsenic exposure can cause gut microbiota dysbiosis. However, it still unclear whether arsenic-induced gut microbiota dysbiosis plays a role in the arsenic-perturbed metabolic imbalance in the host body. Bile acids are the functional compounds synthesized in host bodies but regulated by gut microbiota. In this study, we exposed C57BL/6 mice to1 ppm arsenic in drinking water for 3 months and investigated whether arsenic exposure affects the bile acid homeostasis in mouse sera and livers and whether it is related to the changes in gut bacteria. We found that arsenic exposure caused the decline of major unconjugated primary bile acids in sera. The ratios of unconjugated bile acids and taurine-conjugated bile acids were also decreased. However, the hepatic level of several primary bile acids, including TMCA, MCA, TCA, was significantly increased in arsenic-treated mice. Secondary bile acids were consistently decreased both in sera and livers by arsenic treatment. Moreover, the relative abundance of Bacteroidetes and Firmicutes was differentially changed by arsenic exposure, which was associated with the bile acid level in sera. In summary, this study demonstrates that arsenic exposure perturbs the bile acid homeostasis and arsenic-induced gut microbiota dysbiosis could play a role in this process, which suggests the important role of gut microbiota in arsenic-associated toxicity. ; Master of Science in Environmental Engineering |
| نوع الوثيقة: | master thesis |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/7ktc-8d03Test; https://cdr.lib.unc.edu/downloads/bn999g36n?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/bn999g36nTest |
| DOI: | 10.17615/7ktc-8d03 |
| الإتاحة: | https://doi.org/10.17615/7ktc-8d03Test https://cdr.lib.unc.edu/downloads/bn999g36n?file=thumbnailTest https://cdr.lib.unc.edu/downloads/bn999g36nTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.53663E66 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/7ktc-8d03 |
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