دورية أكاديمية
Cardiac fibroblast in development and wound healing
| العنوان: | Cardiac fibroblast in development and wound healing |
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| المؤلفون: | Deb, Arjun, Ubil, Eric |
| المصدر: | Journal of Molecular and Cellular Cardiology, 70 |
| سنة النشر: | 2014 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Wt-1, myocyte enhancer factor, extracellular matrix, matrix metalloproteinase, connective tissue growth factor, TGF, Mef, Wound, FGF, Tbx, PDGFR, CTGF, fibroblast growth factor, endothelial–mesenchymal-transition, IL, platelet derived growth factor receptor, T-box transcription factor, transforming growth factor, ECM, PDGF, RAS, Fibroblast, tissue inhibitor of metalloproteinase, EndMT, TIMP, MMP, interleukin, platelet derived growth factor, epithelial–mesenchymal-transition, EMT |
| الوصف: | Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise approximately two-thirds of the total number of cardiac cell types. During development, epicardial cells undergo epithelial-mesenchymal-transition to generate cardiac fibroblasts that subsequently migrate into the developing myocardium to become resident cardiac fibroblasts. Fibroblasts form a structural scaffold for the attachment of cardiac cell types during development, express growth factors and cytokines and regulate proliferation of embryonic cardiomyocytes. In post natal life, cardiac fibroblasts play a critical role in orchestrating an injury response. Fibroblast activation and proliferation early after cardiac injury are critical for maintaining cardiac integrity and function, while the persistence of fibroblasts long after injury leads to chronic scarring and adverse ventricular remodeling. In this review, we discuss the physiologic function of the fibroblast during cardiac development and wound healing, molecular mediators of activation that could be possible targets for drug development for fibrosis and finally the use of reprogramming technologies for reversing scar. This article is part of a Special Issue entitled "Myocyte-Fibroblast Signalling in Myocardium." |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/4q65-sj66Test; https://cdr.lib.unc.edu/downloads/73666c19x?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/73666c19xTest |
| DOI: | 10.17615/4q65-sj66 |
| الإتاحة: | https://doi.org/10.17615/4q65-sj66Test https://cdr.lib.unc.edu/downloads/73666c19x?file=thumbnailTest https://cdr.lib.unc.edu/downloads/73666c19xTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.124DD5CA |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/4q65-sj66 |
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