دورية أكاديمية
Cognition, Aryl Hydrocarbon Receptor Repressor Methylation, and Abstinence Duration-Associated Multimodal Brain Networks in Smoking and Long-Term Smoking Cessation
| العنوان: | Cognition, Aryl Hydrocarbon Receptor Repressor Methylation, and Abstinence Duration-Associated Multimodal Brain Networks in Smoking and Long-Term Smoking Cessation |
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| المؤلفون: | Qi, Shile, Fu, Zening, Wu, Lei, Calhoun, Vince D., Zhang, Daoqiang, Daughters, Stacey B., Hsu, Ping-Ching, Jiang, Rongtao, Vergara, Victor M., Sui, Jing, Addicott, Merideth A. |
| المصدر: | Frontiers in Neuroscience, 16 |
| سنة النشر: | 2022 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | smokers, ex-smokers, methylation, multimodal fusion, tobacco, cognition, cessation, neuroimaging |
| الوصف: | Cigarette smoking and smoking cessation are associated with changes in cognition and DNA methylation; however, the neurobiological correlates of these effects have not been fully elucidated, especially in long-term cessation. Cognitive performance, percent methylation of the aryl hydrocarbon receptor repressor (AHRR) gene, and abstinence duration were used as references to supervise a multimodal fusion analysis of functional, structural, and diffusion magnetic resonance imaging (MRI) data, in order to identify associated brain networks in smokers and ex-smokers. Correlations among these networks and with smoking-related measures were performed. Cognition-, methylation-, and abstinence duration-associated networks discriminated between smokers and ex-smokers and correlated with differences in fractional amplitude of low frequency fluctuations (fALFF) values, gray matter volume (GMV), and fractional anisotropy (FA) values. Long-term smoking cessation was associated with more accurate cognitive performance, as well as lower fALFF and more GMV in the hippocampus complex. The methylation- and abstinence duration-associated networks positively correlated with smoking-related measures of abstinence duration and percent methylation, respectively, suggesting they are complementary measures. This analysis revealed structural and functional co-alterations linked to smoking abstinence and cognitive performance in brain regions including the insula, frontal gyri, and lingual gyri. Furthermore, AHRR methylation, a promising epigenetic biomarker of smoking recency, may provide an important complement to self-reported abstinence duration. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/a1jh-zg87Test; https://cdr.lib.unc.edu/downloads/4b29bg49b?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/4b29bg49bTest |
| DOI: | 10.17615/a1jh-zg87 |
| الإتاحة: | https://doi.org/10.17615/a1jh-zg87Test https://cdr.lib.unc.edu/downloads/4b29bg49b?file=thumbnailTest https://cdr.lib.unc.edu/downloads/4b29bg49bTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.93C4E244 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/a1jh-zg87 |
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