دورية أكاديمية
Comparison of the Modified Early Treatment Diabetic Retinopathy Study and Mild Macular Grid Laser Photocoagulation Strategies for Diabetic Macular Edema
| العنوان: | Comparison of the Modified Early Treatment Diabetic Retinopathy Study and Mild Macular Grid Laser Photocoagulation Strategies for Diabetic Macular Edema |
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| المؤلفون: | Diabetic Retinopathy Clinical Research Network |
| المصدر: | Archives of Ophthalmology, 125(4) |
| سنة النشر: | 2007 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Ophthalmology, Surgery, Laser, Diabetes mellitus, Macula, Chirurgie, Etude comparative, Photocoagulation, Endocrinopathie, Early stage, Endocrinopathy, Oeil pathologie, Treatment, Stratégie, Oftalmología, Strategy, Eye disease, Rétinopathie, Retinopathy, Stade précoce, Diabète, Comparative study, Edema, Ophtalmologie, Oedème, Traitement, Tratamiento |
| الوصف: | OBJECTIVE: To compare 2 laser photocoagulation techniques for treatment of diabetic macular edema: the modified Early Treatment Diabetic Retinopathy Study (ETDRS) direct/grid photocoagulation technique and a potentially milder (but potentially more extensive) mild macular grid (MMG) laser technique in which microaneurysms are not treated directly and small mild burns are placed throughout the macula, whether or not edema is present. METHODS: Two hundred sixty-three subjects (mean age, 59 years) with previously untreated diabetic macular edema were randomly assigned to receive laser photocoagulation by either the modified ETDRS (162 eyes) or MMG (161 eyes) technique. Visual acuity, fundus photographs, and optical coherence tomography measurements were obtained at baseline and at 3.5, 8, and 12 months. Treatment was repeated if diabetic macular edema persisted. MAIN OUTCOME MEASURE: Change in optical coherence tomography measurements at 12-month follow-up. RESULTS: Among eyes with a baseline central subfield thickness of 250 microm or greater, central subfield thickening decreased by an average of 88 microm in the modified ETDRS group and by 49 microm in the MMG group at 12-month follow-up (adjusted mean difference, 33 microm; 95% confidence interval, 5-61 microm; P = .02). Weighted inner zone thickening by optical coherence tomography decreased by 42 microm in the modified ETDRS group and by 28 microm in the MMG group (adjusted mean difference, 14 microm; 95% confidence interval, 1-27 microm; P = .04); maximum retinal thickening (maximum thickening of the central and 4 inner subfields) decreased by 66 and 39 microm, respectively (adjusted mean difference, 27 microm; 95% confidence interval, 6-47 microm; P = .01), and retinal volume decreased by 0.8 and 0.4 mm3, respectively (adjusted mean difference, 0.3 mm3; 95% confidence interval, 0.02-0.53 mm3; P = .03). At 12 months, the mean change in visual acuity was 0 letters in the modified ETDRS group and 2 letters worse in the MMG group (adjusted mean difference, 2 ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/nat6-2p24Test; https://cdr.lib.unc.edu/downloads/gm80j2320?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/gm80j2320Test |
| DOI: | 10.17615/nat6-2p24 |
| الإتاحة: | https://doi.org/10.17615/nat6-2p24Test https://cdr.lib.unc.edu/downloads/gm80j2320?file=thumbnailTest https://cdr.lib.unc.edu/downloads/gm80j2320Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.68D2B0D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/nat6-2p24 |
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