دورية أكاديمية
Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction
| العنوان: | Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction |
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| المؤلفون: | Randolph, Tiffany C., Broderick, Samuel, Shaw, Linda K., Chiswell, Karen, Mentz, Robert J., Kutyifa, Valentina, Velazquez, Eric J., Gilliam, Francis R., Thomas, Kevin L. |
| المصدر: | Journal of the American Heart Association - Cardiovascular and Cerebrovascular Disease, 6(3) |
| سنة النشر: | 2017 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | heart failure, Journal Article, mortality, race, QRS, sex |
| الوصف: | BACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: We investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12-lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between QRS duration and all-cause mortality and investigate race-QRS and sex-QRS duration interaction. Median QRS duration was 105 ms (interquartile range [IQR], 92-132) with variation by race and sex (P<0.001). QRS duration was longest in white men (111 ms; IQR, 98-139) followed by white women (108 ms; IQR, 92-140), black men (100 ms; IQR, 91-120), and black women (94 ms; IQR, 86-118). Left bundle branch block was more common in women than men (24% vs 14%) and in white (21%) versus black individuals (12%). In black patients, there was a 16% increase in risk of mortality for every 10 ms increase in QRS duration up to 112 ms (hazard ratio, 1.16; 95% CI, 1.07, 1.25) that was not present among white patients (interaction, P=0.06). CONCLUSIONS: Black individuals with heart failure had a shorter QRS duration and more often had non-left bundle branch block morphology than white patients. Women had left bundle branch block more commonly than men. Among black patients, modest QRS prolongation was associated with increased mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/fjta-bt66Test; https://cdr.lib.unc.edu/downloads/3b591f27t?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/3b591f27tTest |
| DOI: | 10.17615/fjta-bt66 |
| الإتاحة: | https://doi.org/10.17615/fjta-bt66Test https://cdr.lib.unc.edu/downloads/3b591f27t?file=thumbnailTest https://cdr.lib.unc.edu/downloads/3b591f27tTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.C573A081 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/fjta-bt66 |
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