دورية أكاديمية
Mechanotransduction and nuclear function
| العنوان: | Mechanotransduction and nuclear function |
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| المؤلفون: | Graham, David M, Burridge, Keith |
| المصدر: | Current Opinion in Cell Biology, 40 |
| سنة النشر: | 2016 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Cell Nucleus, Membrane Proteins, Chromatin, Cell Differentiation, Mechanotransduction, Cellular, Nuclear Lamina, Cytoskeleton, Nuclear Envelope, Microtubules, Nuclear Proteins, Animals, Signal Transduction, Humans |
| الوصف: | Many signaling pathways converge on the nucleus to regulate critical nuclear events such as transcription, DNA replication and cell cycle progression. While the vast majority of research in this area has focused on signals generated in response to hormones or other soluble factors, the nucleus also responds to mechanical forces. During the past decade or so, much has been learned about how mechanical force can affect transcription, as well as the growth and differentiation of cells. Much has also been learned about how force is transmitted via the cytoskeleton to the nucleus and then across the nuclear envelope to the nuclear lamina and chromatin. In this brief review, we focus on some of the key proteins that transmit mechanical signals across the nuclear envelope. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/pzkr-pk73Test; https://cdr.lib.unc.edu/downloads/5t34sq506?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/5t34sq506Test |
| DOI: | 10.17615/pzkr-pk73 |
| الإتاحة: | https://doi.org/10.17615/pzkr-pk73Test https://cdr.lib.unc.edu/downloads/5t34sq506?file=thumbnailTest https://cdr.lib.unc.edu/downloads/5t34sq506Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.4C324A2E |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/pzkr-pk73 |
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