دورية أكاديمية
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
| العنوان: | Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells |
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| المؤلفون: | Han, Xiaoyun, Sheng, Xiugui, Jones, Hannah M, Jackson, Amanda L, Kilgore, Joshua, Stine, Jessica E, Schointuch, Monica N, Zhou, Chunxiao, Bae-Jump, Victoria L |
| المصدر: | Journal of Hematology & Oncology, 8(1) |
| سنة النشر: | 2015 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | L-Lactate Dehydrogenase, Cell Line, Tumor, Isocoumarins, Blotting, Western, Enzyme Inhibitors, Humans, Cell Proliferation, Glycolysis, Female, Antineoplastic Agents, Endometrial Neoplasms, Apoptosis |
| الوصف: | High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavin, as a therapeutic agent for endometrial cancer. Our results revealed that Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis.Electronic supplementary materialThe online version of this article (doi:10.1186/s13045-014-0097-x) contains supplementary material, which is available to authorized users. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/70z8-m344Test; https://cdr.lib.unc.edu/downloads/73666c14j?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/73666c14jTest |
| DOI: | 10.17615/70z8-m344 |
| الإتاحة: | https://doi.org/10.17615/70z8-m344Test https://cdr.lib.unc.edu/downloads/73666c14j?file=thumbnailTest https://cdr.lib.unc.edu/downloads/73666c14jTest |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.6535FAEB |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/70z8-m344 |
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